Young adults and children living in a high-risk environment and exposed to physical or sexual abuse, migration, cannabis consumption or problematic alcohol use are more likely to grow up as violent adults, finds a new study.

‘Young adults and children living in high-risk conditions are more likely to become violent during their adulthood.’

In a previous study, the researchers reported that schizophrenia could develop about ten years earlier in genetically predisposed people who grow up in high-risk conditions, such as suffering childhood maltreatment, sexual abuse or head trauma. 




As demonstrated in the present study, the same high-risk conditions led to a five times’ greater likelihood of a person being hospitalized in forensic units because of violent behaviour.
For this work, the researchers analyzed data from six different study populations. Overall, the data stemmed from more than 1500 people living with schizophrenia (accessed through the Göttingen Research Association for Schizophrenia, GRAS), as well as more than 550 members of Spain’s general population.
The researchers factored in aspects such as whether the person grew up in an at-risk area, namely if he or she was living in a big city or had migrated, experienced forms of physical or sexual abuse or used cannabis or engaged in problematic alcohol consumption before the age of 18 years.
As outcome measure, the researchers evaluated whether study participants had been convicted of violent crimes such as sexual assault, manslaughter, battery or murder.
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When all high-risk factors were considered together, a person with high risk load (three or more of these risk factors) was ten times more likely to become violently aggressive.
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Subsequently, the researchers carried out comprehensive epigenetic analyses of the blood samples of a subgroup of 142 people. Higher levels of histone-deacetylase1 (HDAC1) mRNA were found in the samples of 33 men with high-risk profile. HDAC1 is an ’umbrella mediator’ of epigenetic processes and changes that can be influenced by environmental factors. "This is a first small hint of epigenetic alterations in our high-risk subjects," says Ehrenreich.
"The results of this study should motivate socio-political actions, aiming at identifying individuals-at-risk and improving precautionary measures," she adds. "Risk factors, interchangeable in their long-term consequences, like urbanicity, migration, and substance abuse, should be increasingly considered through more intensive research into primary prevention."
Source-Eurekalert