The general perception is that chemotherapy works like antibiotics do, by directly killing off what is harmful to the body.
But new research published online on April 4 in the Cell Press journal Immunity shows that effective chemotherapies actually work by mobilizing the body's own immune cells to fight cancer. Researchers found that chemo-treated dying tumors secrete a factor that attracts certain immune cells, which then ingest tumor proteins and present them on their surfaces as alert signals that an invader is present. This new understanding of how chemotherapy works with our immune systems could prompt new tactics for treating cancer.
Chemotherapy
''Chemo'' means medicine or ''drug'', ''therapy'' means ''treatment''. Chemotherapy refers to the use of cytotoxic drugs in the treatment of cancer.
Advertisement
"Successful chemotherapeutics convert the tumor into a therapeutic vaccine, hence mobilizing the host's immune system against the cancer," explains senior author Dr. Guido Kroemer, of the Institut Gustave Roussy, in France.
Dr. Kroemer and his colleagues found that when chemotherapy kills and bursts open cancer cells, the cells release a factor called ATP. The factor recruits immune cells to the tumor site, where they are educated to acquire their function—namely, to ingest and present tumor proteins on their surfaces. The researchers found that when these trained immune cells are blocked, chemotherapy (specifically, anthracyclines) cannot efficiently reduce the growth of tumors in mice. Also, when these trained immune cells are injected into other mice, the mice can fight off cancer cells that are subsequently injected.
![Chemotherapy Drugs]( "Chemotherapy Drugs")
Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body.
The findings point to a new strategy to improve cancer treatments. "Anticancer therapies and immunotherapies might be combined in a way to optimize the local recruitment and function of immune cells—for instance, by increasing extracellular ATP levels—with the goal of boosting the chemotherapy-induced anticancer immune response," says Dr. Kroemer. Also, measuring the recruitment of immune cells to tumor sites after chemotherapy might help predict how well a patient's cancer will respond to the treatment.
Source: Eurekalert
Chemotherapy Drugs
Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body.
Advertisement
The findings point to a new strategy to improve cancer treatments. "Anticancer therapies and immunotherapies might be combined in a way to optimize the local recruitment and function of immune cells—for instance, by increasing extracellular ATP levels—with the goal of boosting the chemotherapy-induced anticancer immune response," says Dr. Kroemer. Also, measuring the recruitment of immune cells to tumor sites after chemotherapy might help predict how well a patient's cancer will respond to the treatment.
Source: Eurekalert
Toxoplasmosis
Brief overview of a common disease called Toxoplasmosis and its risks in human population
Advertisement
Advertisement
|
Advertisement
Recommended Readings
Latest Cancer News
Study reveals five years of disease-freedom among postmenopausal patients aged 50-69, diagnosed with breast cancer.
Engaging in regular exercise could significantly enhance the quality of life for individuals facing metastatic breast cancer.
Drugs known as glucagon-like peptide-1 receptor agonists, prescribed for type 2 diabetes, could lower the likelihood of developing colorectal cancer.
Researchers found a pathway linked to allergies that, when blocked, triggers antitumor immunity in lung cancer mouse models.
The occurrence of epimutations early in pregnancy challenges traditional theories related to carcinogenesis and the risk of developing breast cancer.