A new study published in the journal Cell reveals that the composition of gut microbes change dramatically during pregnancy and while this change is often associated with metabolic diseases, they are beneficial for pregnant women.
"This is the first in-depth characterization of the gut microbiota associated with pregnancy," says senior study author Ruth Ley of Cornell University. "The findings suggest that our bodies have coevolved with the microbiota and may actually be using them as a tool—to help alter the mother's metabolism to support the growth of the fetus."
In nonpregnant animals, changes to gut microbe composition can cause symptoms of metabolic syndrome, including weight gain, abnormal glucose metabolism, and inflammation—an immune response that normally protects the body but can cause health problems. These symptoms also appear during pregnancy, but the underlying causes have been unclear, and few studies have examined the potential link to gut microbiota during pregnancy.
When gut microbes from pregnant women were transferred to healthy germ-free mice, animals that received microbes from the third trimester became fatter and had higher levels of inflammation markers and worse glucose metabolism than mice that received microbes from the first trimester.
"By the third trimester, the microbiota can induce changes in metabolism," Ley says. "In the context of pregnancy, these metabolic changes in the mother are healthy, because they promote energy storage in fat tissue and help support the fetus. Outside of pregnancy, however, these changes can lead to the development of type 2 diabetes and other health problems."