About My Health Careers Internship MedBlogs Contact us

Century Old Henry Ford's Ideas may Cut the Cost and Speed Production of Medicines

by Bidita Debnath on September 9, 2013 at 10:41 PM
Font : A-A+

 Century Old Henry Ford's Ideas may Cut the Cost and Speed Production of Medicines

Ideas that Henry Ford taught a century ago about the advantages of continuous mass production are finding their way into the manufacture of one of the few remaining products still made batch-wise.

These are the billions of tablets, capsules and other forms of medicine that people take each year. That change-over from making medicines in individual batches to continuous output was the topic of a keynote address here at the 246th National Meeting & Exposition of the American Chemical Society (ACS), the world's largest scientific society.


The meeting, which just opened and continues through Thursday, includes almost 7,000 presentations on new advances in science and other topics, and a large exposition of scientific instruments and other products. Thousands of scientists and others are expected to attend the sessions, in the Indiana Convention Center and downtown hotels.

"The difference between batch and continuous processing is somewhat like the difference between a ferry boat and a bridge for getting cars and people across a river," explained Bret E. Huff, Ph.D., who is with Eli Lilly and Company here in Indianapolis. "A ferry moves cars across a river one batch at a time. A bridge provides a continuous flow of cars across the river. A bridge is typically open, with the flexibility to meet demand, without having a line-up of cars waiting for the next trip across."

In the traditional approach for producing medicine, a batch of ingredients would typically undergo a series of batch-wise reactions with isolation of solid intermediates before finally being isolated and drummed into bulk containers. The active pharmaceutical ingredient then moves on to the next step, processing into a granular form, followed by collecting into bulk containers. The processing continues through drying and other stages before being compressed into tablets and coated.

Huff pointed out that small amounts of the ingredients inevitably are lost and wasted at each step, with other inefficiencies taking their toll. And it may take days or weeks to finish each batch of medicine.

In continuous processing, in contrast, the individual batch steps occur continuously, as the ingredients move through the production process in assembly-line fashion. Quality-control testing and other monitoring are not necessarily separate operations done at the end of production of each batch, but can be fully integrated into the continuous-flow operation.

Continuous processing is used in most other large-scale manufacturing such as food production, petroleum refinement and water treatment, Huff noted. Some industries use an extreme version. Blast furnaces that produce iron from iron ore, for instance, may operate non-stop or with only brief pauses for 8-10 years. The machines that produce window glass run continuously for up to 18 years.

The pharmaceutical industry has continued to use traditional production methods for a number of reasons, Huff said. In the past, for instance, the technology did not exist to continuously produce drugs along a production line to ensure quality and purity. Pharmaceutical companies lacked experience with continuous processing and faced the capital costs of redesigning production lines. The U.S. Food and Drug Administration, however, has been assuring companies that there are no scientific, regulatory or other hurdles to adopting continuous processing. And the approach has many benefits, including reduced costs of making medicines, faster production and greater flexibility to tailor production to demand.

Doubling the number of tablets produced in a batch process, for instance, typically would require doubling the amount of production equipment. Continuous production, in contrast, typically offers the flexibility to increase output to meet demand.

"By early next year, Eli Lilly and Company will have installed and demonstrated four different continuous-processing platforms," Huff said. "Currently, almost all of our potential medicines that are in development have continuous-processing steps in place."

Huff's talk was among hundreds of presentations that will connect with the ACS meeting theme, "Chemistry in Motion." The theme presentations will showcase contemporary research and future technologies likely to transform transportation and other areas of life in the 21st century. Topics range from biofuels and alternative energy to lightweight materials and new ways of reducing the effects of friction, which impacts fuel economy.

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
Breast Cancer Awareness Month 2021 - It's time to RISE
First-Ever Successful Pig-To-Human Kidney Transplantation
World Osteoporosis Day 2021 -
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Laser Vision Correction Surgery 

Recommended Reading
Benefits of Blood Pressure Tablets on your Health
Hypertension affects about a billion individuals worldwide and is a silent killer. Medication & ......
Study Proves Coffee, Tea, Caffeine Energy Drinks or Tablets Help Prevent Road Crash Risk
Those who say coffee, tea, caffeine energy drinks or tablets prevent dangerous drowsiness while ......
Medication Poisoning in Children, Explained
Medication poisoning in children is a concerning public health problem....
Haryana Sets Up Helpline After 900 Fall Sick
A helpline will be set up to help students who show any side-effects after being given iron-folic .....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Laser Vision Correction Surgery
Techniques using laser allow faster recovery rates when compared to the older modalities. LASIK is t...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use