About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Cellular Effects of Vitamin A Overdose and Deficiency Explained

by Rajashri on October 10, 2009 at 8:52 PM
Font : A-A+

 Cellular Effects of Vitamin A Overdose and Deficiency Explained

Vitamin A plays a crucial role in energy production within cells, according to research published online in the FASEB Journal. The research also explains why too much or too little has a complex negative effect on our bodies.

This is particularly important as combinations of foods, drinks, creams, and nutritional supplements containing added vitamin A make an overdose more possible than ever before.

Advertisement

"Our work illuminates the value and potential harm of vitamin A use in cosmetic creams and nutritional supplements," said Ulrich Hammerling, co-author of the study, from the Sloan-Kettering Institute for Cancer Research in New York. "Although vitamin A deficiency is not very common in our society, over-use of this vitamin could cause significant disregulation of energy production impacting cell growth and cell death."

Although the importance of vitamin A to human nutrition and fetal development is well-known, it has been unclear why vitamin A deficiencies and overdoses cause such widespread and profound harm to our organs, until now. The discovery by Hammerling and colleagues explains why these effects occur, while also providing insight into vitamin A's anti-cancer effects. The scientists used cultures from both human and mice cells containing specific genetic modifications of the chemical pathways involved in mitochondrial energy production. The cells were then grown with and without vitamin A, and scientists examined the impact on the various steps of energy production. Results showed that retinol, the key component of vitamin A, is essential for the metabolic fitness of mitochondria and acts as a nutritional sensor for the creation of energy in cells. When there is too much or too little vitamin A, mitochondria do not function properly, wreaking havoc on our organs.
Advertisement

"Beauty might be only skin deep, but vitamin A isn't. It goes to the nucleus of our cells and can affect our health for better or worse," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "Using too many products enriched with vitamin A could lead to negative, even fatal, consequences."



Source: Eurekalert
RAS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge on Liver Transplantation
Organ Donation Week 2022 - 'Take the Pledge to Save Lives'
Test your Knowledge on Heart Transplantation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Calcium and Vitamin Supplements Vitamin Supplements Vitamin C / Ascorbic acid Vitamin B6 Vitamin B9 Vitamin B-12 Vitamin-F Food Combinations that Affect Your Well-being Mango Health Benefits Top Foods for Naturally Glowing Face and Radiant Skin 

Most Popular on Medindia

Nutam (400mg) (Piracetam) Pregnancy Confirmation Calculator Loram (2 mg) (Lorazepam) Daily Calorie Requirements Accident and Trauma Care Drug Side Effects Calculator Diaphragmatic Hernia Calculate Ideal Weight for Infants Find a Doctor How to Reduce School Bag Weight - Simple Tips
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use