For patients with atrial fibrillation and heart failure, catheter ablation was found superior to conventional drug therapy. Findings are published in Annals of Internal Medicine.
Atrial fibrillation is associated with thromboembolic stroke, systemic embolism, and decompensated heart failure. The benefits and harms of catheter ablation versus drug therapy for patients with atrial fibrillation have not been firmly established.
Researchers from Icahn School of Medicine at Mount Sinai reviewed six published randomized controlled trials to compare the benefits and harms between catheter ablation and standard drug therapy (rate or rhythm control medications) in adult patients with atrial fibrillation and heart failure. Their analysis showed that compared to medication, catheter ablation was associated with reductions in all-cause mortality and heart failure hospitalizations and improvements in left ventricular ejection fraction; quality of life; cardiopulmonary exercise capacity; and 6-minute walk test distance, with no statistically significant increase in serious adverse events.
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