For patients with atrial fibrillation and heart failure, catheter ablation was found superior to conventional drug therapy. Findings are published in Annals of Internal Medicine.
Atrial fibrillation is associated with thromboembolic stroke, systemic embolism, and decompensated heart failure. The benefits and harms of catheter ablation versus drug therapy for patients with atrial fibrillation have not been firmly established.
Atrial Fibrillation
Atrial fibrillation may not be life-threatening in itself but it is important to understand the causes, symptoms and treatments because of the risk of life-threatening complications.
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‘Catheter ablation is an established therapeutic strategy for atrial fibrillation, but guidelines recommend caution in certain patients. ’
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Researchers from Icahn School of Medicine at Mount Sinai reviewed six published randomized controlled trials to compare the benefits and harms between catheter ablation and standard drug therapy (rate or rhythm control medications) in adult patients with atrial fibrillation and heart failure. Their analysis showed that compared to medication, catheter ablation was associated with reductions in all-cause mortality and heart failure hospitalizations and improvements in left ventricular ejection fraction; quality of life; cardiopulmonary exercise capacity; and 6-minute walk test distance, with no statistically significant increase in serious adverse events.
The major adverse events rates observed in the pooled analysis were 7.2 percent in the ablation group and 3.8 percent in the standard therapy group. Despite the complications associated with catheter ablation, the authors explain that the long-term benefits in all-cause mortality, heart failure hospitalizations, and overall clinical outcomes must be weighed in clinical decision making.
Media contact: For an embargoed PDF, please contact Lauren Evans at laevans@acponline.org. To interview the lead author, Vivek Reddy, MD, please contact Wendi Chason at wendi.chason@mountsinai.org.
Source: Eurekalert
Media contact: For an embargoed PDF, please contact Lauren Evans at laevans@acponline.org. To interview the lead author, Vivek Reddy, MD, please contact Wendi Chason at wendi.chason@mountsinai.org.
Source: Eurekalert
Quiz on Atrial Fibrillation
Atrial fibrillation is a condition associated with increased heart rate and irregular rhythm, which requires immediate attention. Test your knowledge on atrial fibrillation by taking this quiz.
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