Removing one carotid body from some patients with hypertension (high blood pressure) can provide sustained fall in blood pressure, finds new research.

"The falls in blood pressure are impressive -- more than pharmacological medication -- and demonstrate the potential for targeting the carotid body to treat hypertension," said Angus Nightingale, researcher at the University of Bristol, England.
The carotid bodies detect the levels of oxygen in blood and when this falls they raise the alarm of a potential emergency by signalling to the brain to increase breathing and blood pressure.
High blood pressure treatment typically tackles the symptoms targeting the end organs such as the heart, kidneys and blood vessels, and not the causes," said Julian Paton, researcher at the University of Bristol, England.
The clinical trial demonstrated that the carotid bodies in patients who responded to resection had raised carotid body activity. These patients breathed more at rest and produced exaggerated breathing responses when the oxygen level in their blood was lowered.
"Although this surgical approach to controlling high blood pressure was successful, we don't think this will be the solution in the long term. We now need to find a drug that dampens down an overactive carotid body and resets the blood pressure thermostat to a normal level," Nightingale added.
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