About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

'Cantonese Cancer' could be Explained by 3 Genetic Variants, Say Scientists

by Thilaka Ravi on May 31, 2010 at 11:17 AM
Font : A-A+

 'Cantonese Cancer' could be Explained by 3 Genetic Variants, Say Scientists

Flaws in three genes could help explain the high incidence of a type of nose and throat cancer in parts of southern China , scientists said on Sunday.

Experts from China, Singapore and the United States trawled through a genetic datamine of around 10,000 people of southern Chinese descent.

Advertisement

Half of the volunteers had been diagnosed with nasopharyngeal carcinoma, a cancer that forms in the lining of the upper throat lying behind the nose. The other half were otherwise healthy.

What showed up in the cancer group were telltale variants in three genes, according to the research, reported in the journal Nature Genetics.

The three, named TNFRSF19, MDSIEVI1 and CDKN2A/2B, have been previously linked with leukaemia.
Advertisement

Another pointer in the cancer patients was a variation in the human leukocyte antigen (HLA) gene, which has previously been fingered in this disease.

The findings are important, says the study, as they could shed light on the molecular pathways of nasopharyngeal carcinoma and its high prevalence in southern China, especially Guangdong province.

In this region, the cancer occurs in about 25 cases per 100,000 people, which is 25 times higher than the rest of the world. As a result, nasopharyngeal carcinoma is sometimes called the "Cantonese cancer."

Only Alaska, parts of northern Africa and southeastern Asia have similarly high rates.

The research was led by the Genome Institute of Singapore and the Sun Yat-Sen University Cancer Centre in Guangzhou.

Nose and throat cancers have lifestyle as well as inherited factors. Smoking, in particular, is a major cause. In nasopharyngeal carcinoma, consumption of salted and pickled foods as well as high levels in the blood of Epstein-Barr virus are additionally in the spotlight.

Source: AFP
THK
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge About Chromosomes?
Eating During Sunlight Hours Minimizes Mood Vulnerabilities
Know More About the Digestive System
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Genetics and Stem Cells Christianson Syndrome 

Most Popular on Medindia

Vent Forte (Theophylline) Blood - Sugar Chart Noscaphene (Noscapine) A-Z Drug Brands in India Nutam (400mg) (Piracetam) Indian Medical Journals Daily Calorie Requirements Drug Side Effects Calculator Loram (2 mg) (Lorazepam) Color Blindness Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

'Cantonese Cancer' could be Explained by 3 Genetic Variants, Say Scientists Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests