A new study has indicated that combination of drugs inhibiting receptor tyrosine kinases (RTKs)and targeting inhibitors of apoptosis (IAP) may improve cancer therapy efficacy.
Previous studies have shown that therapeutics targeting RTKs would likely be beneficial to individuals with glioblastoma multiforme (GBM), one of the most aggressive types of brain tumour.
However, a small proportion of patients respond to such treatment and most subsequently relapse after only a short time.
The team found that final steps of this pathway were blocked by a group of proteins known as IAPs.
The study suggested that if the PDGFR inhibitor was combined with an IAP inhibitor the GBM cells underwent apoptosis.
Further, this drug combination showed enhanced efficacy at stalling tumour growth in an orthotopic mouse model of GBM.
The authors revealed that combining drugs targeting IAPs with RTK inhibitors might prove beneficial to individuals with GBM.