A new mechanism involving a signaling protein and its receptor that could block the formation of new blood vessels and cancer growth has been demonstrated by researchers at the Boston University School of Medicine (BUSM).
Angiogenesis creates new blood vessels in a process that can lead to the onset and progression of several diseases such as cancer and age-related macular degeneration.
Vascular endothelial growth factor (VEGF) is a signaling protein produced by damaged cells, which binds to one of its receptors VEGFR-2, located on the surface of blood vessel cells.
Once VEGF is bound to its receptor, it is activated and sends a biochemical signal to the inside of the blood vessel cell to initiate angiogenesis.
There are currently multiple Federal Drug Administration-approved medications that target this process.
However, these medications are limited by insufficient efficacy and the development of resistance.
The researchers demonstrated that a biochemical process called methylation, which can regulate gene expression, also affects VEGFR-2, and this can lead to angiogenesis.
Using multiple methods, the researchers were able to interfere with the methylation process of VEGFR-2 and subsequently block angiogenesis and tumor growth.
"The study points to the methylation of VEGFR-2 as an exciting, yet unexplored drug target for cancer and ocular angiogenesis, ushering in a new paradigm in anti-angiogenesis therapy," Nader Rahimi, PhD, associate professor of pathology, BUSM, who served as the study's senior investigator, said.
The findings are published in the journal Science Signaling.