Cancer-fighting Nanobots Could be Directed by Whip-tailed Bacteria

Bacteria injected into blood stream could sound an 'alarm' to nanobots in the body so that they sense tumour cells and release anticancer drugs to fight them, scientists at Polytechnic University of Catalonia in Barcelona, Spain, have said.

Maria Gregori and Ignacio Llatser came up with the idea of encoding a message in a DNA sequence that is inserted into each non-pathogenic strain of E. coli bacterium's cytoplasm.

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Each nanobot would contain bacteria inscribed with every message that could be needed.

Upon encountering a tumour, the nanobot would release the correctly encoded bacteria. These would then swim towards other nanobots, attracted by the nutrients stored there.

Once there, the encoded DNA sequence binds with chemical receptors and its message - telling it where to swarm or to release its drugs - is acted upon.

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In a computer simulation, the pair found bacteria that had flagella took about 6 minutes to traverse a distance of 1 millimetre from a transmitting to a receiving nanobot.

"That's a bandwidth of 1.7 kilobits per second. It's not high, but for the biomedical applications we envisage it should be [fast] enough," New Scientist quoted Llatser as saying.

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Not everyone is convinced about the results though.

"These are just simulation results. Everything is possible in simulation," said Andrew Adamatzky of the unconventional computing department at the University of the West of England in Bristol, UK.

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"While their simulation results seem OK, only experimental evidence will convince me that their technique is working," he added.

The study appears in the journal Computer Networks.

Source-ANI