About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Cancer Drug Trial Showed Unexpected Results

by Bidita Debnath on April 8, 2014 at 11:54 PM
Font : A-A+

 Cancer Drug Trial Showed Unexpected Results

Research has shown a drug, used in combination with chemotherapy to treat advanced colorectal cancer is not effective in some settings and indeed may result in more rapid cancer progression.

The research took place at the University of Southampton. The New EPOC study, published in The Lancet Oncology and funded by Cancer Research UK, evaluated whether the drug cetuximab and chemotherapy together worked better than chemotherapy alone as a treatment in addition to surgery for people with bowel cancer that had spread to the liver but could be surgically removed. In the trial patients either received chemotherapy on its own or chemotherapy combined with cetuximab. Patients received their specified treatment for 12 weeks. They then had surgery and followed by their specified treatment for another 12 weeks. Patients were then monitored via CT or MRI scans.

Advertisement

The researchers found that adding cetuximab to chemotherapy did not help this group of people. Analysis looked at how long people in each group were living without any sign of their cancer getting worse. They found this was on average 14.1 months in the group having chemotherapy and cetuximab compared to 20.5 months in the group having chemotherapy alone.

John Primrose, Professor of Surgery at the University of Southampton, comments: "These results were unexpected. Cetuximab is already approved by NICE alongside chemotherapy for people who had bowel cancer that had spread to the liver if the oncologist and liver surgeon thought this would enable the patient to have a liver operation. The cetuximab and chemotherapy combination is also used successfully in patients whose disease cannot be operated on at all. Our trial tested it in people who had cancer spread to the liver who were suitable for surgery from the outset, a similar group, but for these patients it seems to have an adverse effect. More research is needed to understand this surprising result."
Advertisement

Professor Primrose, also a consultant surgeon at Southampton General Hospital, adds: "These are very important data and we would like to thank the patients and relatives of patients those who took part in this trial, as well as the many clinicians in the UK who participated. Our results demonstrate the importance of clinical trials to ensure patients with cancer receive the best of treatment for their condition."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Is COVID-19 Vaccination during Pregnancy Safe?
Sensory Processing Disorder (SPD)
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Clinical Trials Cancer and Homeopathy Clinical Trials - The Past and The Future Clinical Trials - Different Phases of the trial Signature Drug Toxicity Cancer Facts Cancer Tattoos A Body Art Oncology Drug Delivery Systems 

Recommended Reading
Experimental Anticancer Drug Reverses Schizophrenia
In mice, experimental cancer drug reverses behaviors associated with schizophrenia, reveals study....
Research Reveals Combining Cell Replication Blocker With Common Cancer Drug Kills Resistant Tumor Cells
An agent that inhibits mitochondrial division can overcome tumor cell resistance to a commonly used ...
New Research Finds Recurrent Head and Neck Tumors Have Gene Mutations That Could be Vulnerable to Cancer Drug
While metastatic and primary tumor cells of head and neck cancers share similar mutations, ......
Significant Breakthrough in Developing New Cancer Drugs
Researchers recently achieved a significant breakthrough thanks to the laboratory growth of ......
Clinical Trials
Clinical trials are experiments that yield useful information to clinicians if a particular treatmen...
Clinical Trials - Different Phases of the trial
Clinical trials serve as a vital component for improving the treatment of medical conditions as they...
Clinical Trials - The Past and The Future
Many of the drugs that are used today have been discovered by chance or often by mere serendipity...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Oncology Drug Delivery Systems
Drug delivery in oncology offers a localized, prolonged and protected drug interaction with the canc...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use