About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Cancer-Causing Bacteria Wreak Havoc With Tumor-Suppressor Protein

by Tanya Thomas on August 4, 2010 at 11:15 AM
Font : A-A+

 Cancer-Causing Bacteria Wreak Havoc With Tumor-Suppressor Protein

Researchers have discovered a mechanism by which Helicobacter pylori, the only known cancer-causing bacterium, disables a tumor suppressor protein in host cells.

The new study, in the journal Oncogene, reports the discovery of a previously unknown mechanism linking H. pylori infection and stomach cancer, the second leading cause of cancer deaths worldwide.

Advertisement

About two-thirds of the world's population is infected with H. pylori, a bacterium that can survive in the harsh environment of the stomach. Most infected people never develop disease. For a significant minority, however, infection with H. pylori leads to inflammation, ulcers and in some cases, stomach (gastric) cancer.

H. pylori's ability to cause disease is closely associated with a virulence protein called CagA. Previous studies have found that CagA-positive strains are much more likely to cause inflammation and spur the abnormal cell division and growth of cells that lead to cancer.
Advertisement

H. pylori injects CagA into the epithelial cells that line the stomach. Within the cells, CagA is able to hijack various signaling pathways and disrupt proper cellular functions.

Other studies have identified RUNX3 (pronounced RUNKS-three) as an important gastric cancer tumor suppressor.

Loss of expression of RUNX3 is causally associated with the development of gastric cancer, said University of Illinois medical biochemistry professor Lin-Feng Chen, who led the study. RUNX3 guards against tumor formation by spurring the production of factors that target unhealthy cells for destruction.

IMAGE: University of Illinois medical biochemistry professor Lin-Feng Chen and his colleagues discovered a mechanism directly linking a protein associated with H. pylori infection of the stomach and stomach cancer....
Click here for more information.




Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Shigellosis MRSA - The Super Bug Food Safety for Health Antibiotics 

Most Popular on Medindia

Color Blindness Calculator Calculate Ideal Weight for Infants Selfie Addiction Calculator Sanatogen Turmeric Powder - Health Benefits, Uses & Side Effects The Essence of Yoga A-Z Drug Brands in India Hearing Loss Calculator Drug Side Effects Calculator Noscaphene (Noscapine)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Cancer-Causing Bacteria Wreak Havoc With Tumor-Suppressor Protein Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests