About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Can Transgender Women Rely on Medicine Alone to Lower Testosterone Levels?

by Anjali Aryamvally on February 21, 2018 at 12:52 PM
Font : A-A+

Can Transgender Women Rely on Medicine Alone to Lower Testosterone Levels?

Majority of transgender women are unable to reliably lower their testosterone levels into the typical female physiologic range with medicine alone. In a first study of its kind, a research team investigates the efficacy of transgender treatment in its stability to maintain low testosterone levels over a prolonged period of several years. The study is published in the journal Endocrine Practice.

Transgender individuals are those with gender identity different from external sexual anatomy at birth. Recent studies report that 0.6 percent of the adult population in the U.S. identify as transgender. A goal of transgender medical intervention is to align physical appearance with gender identity. The strategy for transgender women (male-to-female) includes medication and/or surgery to decrease or suppress testosterone levels into the female range. Most transgender women depend on medical treatment alone to lower their testosterone levels.

Advertisement


The researchers extracted testosterone and estradiol levels from the electronic medical records of 98 anonymized transgender women treated with oral spironolactone and oral estrogen therapy. Patients were separated into four similarly sized groups using the average estradiol dose they were administered over the course of their treatment. The Endocrine Society guidelines on monitoring transgender women suggests that patients should reach a serum testosterone <50ng/dl.

Only a quarter of transgender women taking a regimen of spironolactone and estrogens were able to lower testosterone levels within the usual female physiologic range. Another quarter could not achieve female levels but remained below the male range virtually all of the time, while one quarter was unable to achieve any significant suppression.
Advertisement

"This study allowed us to identify patients who achieved differing levels of testosterone suppression, including a group of patients unable to achieve any significant testosterone suppression. These patients may have had difficulty adhering to their treatment or may have had a different physiologic response to treatment than other patients. On the other hand, patients who were able to achieve high levels of suppression may have adhered stringently to their treatment or had robust response based on physiology," explained corresponding author Joshua D. Safer, MD, FACP, associate professor of medicine at Boston University School of Medicine.

"Also, it is not known if there is an absolute need for all transgender women to suppress the testosterone levels entirely into the female range. Perhaps it is acceptable for some to have levels just above the usual female upper limit."

The researchers believe future studies could pinpoint specific characteristics of patients who fall into each quartile of average steady state testosterone. "Identification of reasons why certain patients have better testosterone suppression could help improve anti-androgen therapy and allow for targeted interventions to advance the U.S. medical regimen for transgender women. As well, future study could determine the specific impact of testosterone at different levels even if not entirely in the female range," said Safer, also the Medical Director of the Center for Transgender Medicine and Surgery at Boston Medical Center.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Memory Loss - Can it be Recovered?
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Andropause / Male Menopause Adreno Cortical Carcinoma Is Your Man Moody? High Testosterone Level In Women / Hyperandrogenism 

Recommended Reading
Control HIV Epidemics Via Unconventional Approach Suggest UCLA Researchers
Pre-exposure prophylaxis, or PrEP is the new strategy to prevent HIV infection by providing ......
Transgender Youths Twice as Likely to Have Suicidal Thoughts
Transgender adolescents are twice as likely to have suicidal thoughts, and they are up to four ......
Adreno Cortical Carcinoma
Adrenocortical carcinoma is a rare but aggressive form of cancer that affects the outer cortex laye...
Andropause / Male Menopause
Andropause or male menopause causing low libido in a man is due to decreasing level of male hormones...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
High Testosterone Level In Women / Hyperandrogenism
High levels of testosterone in women, also known as hyperandrogenism is an endocrine disorder charac...
Is Your Man Moody?
Women get confused by the behavior of men in their lives. It is time they realize that men too have ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use