Can Severe Sepsis Lead To Heart Disease Development?

by Rishika Gupta on  February 19, 2019 at 7:17 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

Is heart disease development a deadly risk for patients who are hospitalized with sepsis? Yes, it is indeed. In this study, the incidence of cardiovascular disease and in-hospital deaths in patients hospitalized with severe sepsis are being assessed.
 Can Severe Sepsis Lead To Heart Disease Development?
Can Severe Sepsis Lead To Heart Disease Development?

Physician-scientists from the University of Alabama at Birmingham have recently assessed the incidence, or new onset, of cardiovascular disease and in-hospital deaths in patients hospitalized with severe sepsis, a clinical syndrome related to infection and organ dysfunction.

The findings, published in the American Journal of Cardiology, show that the frequency, characteristics, and outcomes of patients with severe sepsis who develop cardiovascular events are not well-known due to a lack of large epidemiologic studies in this population.

UAB's Nirav Patel, M.D., first author of the article, designed and conducted the analyses for the study.

"Sepsis has been recognized as an important cause of cardiovascular morbidity and mortality in the United States," he said. "However, there is a lack of comprehensive exploration on new onset of cardiovascular disease and its impact on in-hospital deaths among adults with severe sepsis."

Sepsis is a systemic inflammatory response to known or suspected infection. Severe sepsis is a form of sepsis that further involves organ dysfunction. Utilizing the "big data" from the New York State Inpatient Database, Patel and investigators from UAB summarized the incidence of cardiovascular disease and hospital deaths among patients admitted with severe sepsis.

As part of the study, researchers conducted a population-based assessment of incident cardiovascular events occurring in patients with severe sepsis and the effect of these cardiovascular events on in-hospital mortality.

Researchers have found nearly one-third of patients admitted with severe sepsis developed cardiovascular disease. Irregular heartbeats were the most common type of cardiovascular disease, followed by a heart attack or stroke and acute heart failure.

Increasing age, white race, male sex, history of heart failure and an increasing number of organs' dysfunct4-ion were important factors related to the new onset of cardiovascular disease in patients with severe sepsis. The occurrence of cardiovascular disease in the setting of severe sepsis was linked with 29 percent higher odds of in-hospital deaths.

Authors highlighted a high burden (approximately 32 percent) of new-onset cardiovascular disease and a significant death risk (29 percent) attributable to cardiovascular disease in severe sepsis.

"The inflammatory response to severe infection in sepsis results in physiologic, biologic and biochemical dysfunction, which may lead to an increase in the risk of cardiovascular disease," said senior author Pankaj Arora M.D., an assistant professor in UAB's Division of Cardiovascular Disease. "Current critical care and cardiology societal guidelines from the International Guidelines for Management of Sepsis and Septic Shock, American College of Cardiology, and American Heart Association lack specific recommendations for surveillance and treatment on new onset of cardiovascular disease in sepsis."

Arora says he sees patients admitted with severe sepsis in intensive care units develop new-onset cardiovascular manifestations frequently, but the cumulative burden has not been well-characterized in the past. Moreover, in-hospital mortality in severe sepsis has not declined in the last few decades. Arora says their work highlights the need for sepsis treatment protocols to be tailored for early recognition and prompt treatment of cardiovascular manifestations.

Arora also emphasizes the need for detailed investigations of cardiovascular physiology in severe sepsis to target specific therapeutic strategies to avoid the new onset of cardiovascular disease and, subsequently, reduce deaths.

Source: Newswise

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

Recommended Reading

More News on:

Cardiac Catheterization Heart Attack Air travel: To fly or not to fly Diet Lifestyle and Heart Disease Body Mass Index Silent Killer Diseases Heart Healthy Heart Lifestyle Paths to Prevent Heart Disease Statins 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive