About My Health Careers Internship MedBlogs Contact us

Can Severe Sepsis Lead To Heart Disease Development?

by Rishika Gupta on February 19, 2019 at 7:17 PM
Font : A-A+

 Can Severe Sepsis Lead To Heart Disease Development?

Is heart disease development a deadly risk for patients who are hospitalized with sepsis? Yes, it is indeed. In this study, the incidence of cardiovascular disease and in-hospital deaths in patients hospitalized with severe sepsis are being assessed.

Physician-scientists from the University of Alabama at Birmingham have recently assessed the incidence, or new onset, of cardiovascular disease and in-hospital deaths in patients hospitalized with severe sepsis, a clinical syndrome related to infection and organ dysfunction.


The findings, published in the American Journal of Cardiology, show that the frequency, characteristics, and outcomes of patients with severe sepsis who develop cardiovascular events are not well-known due to a lack of large epidemiologic studies in this population.

UAB's Nirav Patel, M.D., first author of the article, designed and conducted the analyses for the study.

"Sepsis has been recognized as an important cause of cardiovascular morbidity and mortality in the United States," he said. "However, there is a lack of comprehensive exploration on new onset of cardiovascular disease and its impact on in-hospital deaths among adults with severe sepsis."

Sepsis is a systemic inflammatory response to known or suspected infection. Severe sepsis is a form of sepsis that further involves organ dysfunction. Utilizing the "big data" from the New York State Inpatient Database, Patel and investigators from UAB summarized the incidence of cardiovascular disease and hospital deaths among patients admitted with severe sepsis.

As part of the study, researchers conducted a population-based assessment of incident cardiovascular events occurring in patients with severe sepsis and the effect of these cardiovascular events on in-hospital mortality.

Researchers have found nearly one-third of patients admitted with severe sepsis developed cardiovascular disease. Irregular heartbeats were the most common type of cardiovascular disease, followed by a heart attack or stroke and acute heart failure.

Increasing age, white race, male sex, history of heart failure and an increasing number of organs' dysfunct4-ion were important factors related to the new onset of cardiovascular disease in patients with severe sepsis. The occurrence of cardiovascular disease in the setting of severe sepsis was linked with 29 percent higher odds of in-hospital deaths.

Authors highlighted a high burden (approximately 32 percent) of new-onset cardiovascular disease and a significant death risk (29 percent) attributable to cardiovascular disease in severe sepsis.

"The inflammatory response to severe infection in sepsis results in physiologic, biologic and biochemical dysfunction, which may lead to an increase in the risk of cardiovascular disease," said senior author Pankaj Arora M.D., an assistant professor in UAB's Division of Cardiovascular Disease. "Current critical care and cardiology societal guidelines from the International Guidelines for Management of Sepsis and Septic Shock, American College of Cardiology, and American Heart Association lack specific recommendations for surveillance and treatment on new onset of cardiovascular disease in sepsis."

Arora says he sees patients admitted with severe sepsis in intensive care units develop new-onset cardiovascular manifestations frequently, but the cumulative burden has not been well-characterized in the past. Moreover, in-hospital mortality in severe sepsis has not declined in the last few decades. Arora says their work highlights the need for sepsis treatment protocols to be tailored for early recognition and prompt treatment of cardiovascular manifestations.

Arora also emphasizes the need for detailed investigations of cardiovascular physiology in severe sepsis to target specific therapeutic strategies to avoid the new onset of cardiovascular disease and, subsequently, reduce deaths.

Source: Newswise

News A-Z
News Category
What's New on Medindia
Can Adjusting Fatty Acid Intake Improve Mood in Bipolar Disorder Patients?
Insulin Resistance Doubles the Risk of Major Depressive Disorder
Emotional Healing
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cardiac Catheterization Heart Attack Air travel: To fly or not to fly Diet Lifestyle and Heart Disease Body Mass Index Silent Killer Diseases Heart Healthy Heart Lifestyle Paths to Prevent Heart Disease Statins 

Recommended Reading
Antidepressant Could Save from Deadly Sepsis
Fluvoxamine, the antidepressant, could save people from severe deadly sepsis, according to new ......
Low-fiber, High-fat Western Diet May Increase Severe Sepsis, Death Risk
Eating a Western diet low in fiber, high in fat and sugar can put you at higher risk of severe ......
Basophils Play Key Role in Sepsis Prevention
Secret to sepsis may lie in basophils, a rare group of white blood cells, stated new research....
Fluid Resuscitation for Sepsis Treatment
Fluid resuscitation with restricted amounts of fluid can treat sepsis and hypo-tension....
Air travel: To fly or not to fly
Air travel is for everyone, even those with medical conditions....
Body Mass Index
Body mass index (BMI) is a simple tool that is generally used to estimate the total amount of body f...
Cardiac Catheterization
Cardiac catheterization is a radiological procedure for both diagnosis and treatment of heart condit...
Heart Attack
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the lead...
Lifestyle Paths to Prevent Heart Disease
Heart disease can be of many types depending upon whether they involve the heart muscles or artery w...
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use