About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Brown Coal Substance can Fight Viruses

by Adeline Dorcas on August 19, 2019 at 2:46 PM
Font : A-A+

Brown Coal Substance can Fight Viruses

Natural substance extracted from brown coal can fight against the tick-borne encephalitis virus, reports a new study. The findings of the study are published in the Scientific Reports journal.

Scientists from Russia demonstrated a novel approach leveraging the combination of high-resolution mass spectrometry and chemoinformatics to identify biologically active molecular components of humic substances extracted from coal, and discovered substances with antiviral activity against the tick-borne encephalitis virus.

Advertisement


Natural multicomponent mixtures, such as humic substances found in soil, peat, and coal, are a very important source of biologically active compounds. Understanding their composition and extracting active components can be a great help in creating new drugs. However, finding a specific compound in these environments is a highly challenging task that requires advanced methods capable of differentiating and separating one substance from another.

A joint study conducted by scientists from the Skolkovo Institute of Science and Technology (Skoltech), M.P. Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of the RAS, and M.V. Lomonosov Moscow State University revealed that humic substances inhibit the reproduction of a dangerous human pathogen, tick-borne encephalitis virus.
Advertisement

The authors relied on high-resolution mass spectrometry to study the composition of humic samples and chemoinformatics to analyze their findings. They compared the results against extensive databases of chemical compounds and identified the compounds' structural features which may be responsible for their virucidal activity. The data analysis results clearly attest to the importance of natural central fragments of flavonoids and polyphenols, two classes of natural compounds with wide-ranging biological activity.

"We made an attempt at understanding the structural reasons behind the antiviral activity of the molecular components of humic substances. Aware that standard methods of complex mixture separation do not work for humic substances, we looked at some known structures matching the molecular compositions determinable by mass spectrometry and noticed that some structures correspond to compounds often extracted from natural sources, for example, flavonoids.

We undertook further mass spectrometry experiments, which suggest that there can indeed be a match between the types of structures we found in the databases and the molecular components of humic systems," says one of the authors of the study and Research Scientist at Skoltech, Alexander Zherebker, PhD.

The results of the study can serve as a stepping stone towards detailed research into the molecular mechanisms of biological activity exhibited by humic substances and other natural inseparable multicomponent mixtures and assessment of their pharmaceutical potential.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First-Ever Successful Pig-To-Human Kidney Transplantation
World Osteoporosis Day 2021 -
Spirituality and Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
Encephalitis
Encephalitis is the inflammation of the brain, mostly caused by viruses. Though rare, it is a ......
Antiviral Protein 'Viperin' Hampers Tick-Borne Encephalitis Virus
The protein viperin can prohibit tick-borne encephalitis virus (TBEV) from multiplying in the cell....
Acute Encephalitis Syndrome in India: Could Litchi be the Culprit?
Acute encephalitis syndrome (AES) in Bihar, India has claimed the lives of 133 children so far. It ....
What You Should Know about Japanese Encephalitis
Japanese encephalitis is a mosquito borne viral disease associated with inflammation of the brain....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use