Britain’s Regulator Receives An Application To Genetically Modify An Embryo

Human Fertilization and Embryology Authority (HFEA) in Britain has received an application to genetically modify an embryo, which would be the first such attempt since a Chinese effort earlier this year.

"We have recently received an application to use CRISPR-Cas9 in one of our licensed research projects, and it will be considered in due course," said a HFEA spokesman.

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The CRISPR-Cas9 technique can target and modify faulty DNA with greater accuracy. Kathy Miakan, a stem cell scientist at the Francis Crick Institute in London, said she had asked the HFEA for the license to conduct genome editing on human embryos.

"The knowledge we acquire will be very important for understanding how a healthy human embryo develops, and this will inform our understanding of the causes of miscarriage," told Kathy.

The modified embryos will not become children as they must be destroyed within 14 days and can only be used for basic research. Miakan wants to find the genes at play in the first few days of human fertilization, when an embryo develops a coating of cells that later become the placenta.

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"Genome editing of embryos for use in treatment is illegal. It has been permissible in research since 2009, as long as the research project meets the criteria in the legislation and it is done under an HFEA license," said the HFEA spokesman.

In a research paper published in April, Chinese scientists described how they were able to manipulate the genomes of human embryos for the first time, which raised ethical concerns about the new frontier in science.

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Junjiu Huang, a gene-function researcher at Sun Yat-sen University in Guangzhou, and colleagues describe how they used the CRISPR-Cas9 technique to edit the genomes of embryos obtained from a fertility clinic. The embryos were described as non-viable, and could not have resulted in a live birth because they had an extra set of chromosomes after being fertilized by two sperm.

Source-AFP

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