Brit Scientists Explain Why Arteries Clog Up

by Tanya Thomas on Sep 28 2009 10:49 AM

An enzyme, recently identified by British scientists, reportedly plays a crucial role in clogging up of arteries.

They have discovered that an enzyme called matrix metalloproteinase-8 that raises blood pressure and causes abnormal build-up of cells in the arteries - both of which increase the risk of heart disease.

"Our research tells us that this enzyme plays a crucial role in the build-up of fatty deposits in the arteries which causes heart disease," said lead researcher Shu Ye, Professor of Molecular Medicine and Genetics at Queen Mary, University of London.

"Many patients with high blood pressure or heart failure are currently treated with ACE inhibitor drugs. However, some patients do not respond sufficiently to ACE inhibitors alone.

"We hope that what we've found here could be the basis for new drugs that can enhance the effects of ACE inhibitors, which would reduce deaths from heart disease," Ye added.

During the study, researchers genetically engineered mice to lack the MMP8 enzyme.

The mice were fed on a Western-style diet high in fat and cholesterol and compared to normal mice fed on the same diet.

The mice, which lacked the enzyme, had clearer arteries and lower blood pressure.

The researchers also studied 2,000 patients who were being tested for clogs in arteries leading to their hearts with a test called a coronary angiogram.

They found that around 25 per cent of these patients had a slightly different version of the gene for MMP8 and their arteries were more clogged than other patients.