About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Breathing Capacity Can Be Restored in Duchenne Muscular Dystrophy

by Hannah Joy on September 28, 2017 at 11:14 AM
Font : A-A+

Breathing Capacity Can Be Restored in Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) patients have deficiencies in respiratory capacity and by activating the brain breathing can be restored in these patients, reveals a new study.

Duchenne muscular dystrophy (DMD) is a fatal genetic neuromuscular disease, which can lead to respiratory failure. Respiratory muscle dysfunction is recognized in DMD, however a thorough assessment of nervous system control of respiratory muscles is lacking.

Advertisement


The study was published in The Journal of Physiology.

Lead investigators David Burns and Ken O'Halloran at University College Cork, in conjunction with collaborator labs at the University of Calgary and Trinity College Dublin, performed experiments in mice lacking dystrophin, the muscle protein that malfunctions in DMD.
Advertisement

These mice have been shown to be a useful pre-clinical model of DMD as they demonstrate many of the hallmark features of respiratory muscle dysfunction in DMD patients.

In the young dystrophin-deficient mice, the respiratory control system was impaired on multiple levels. Importantly, the researchers found that the brain was compensating for this by increasing activation of the diaphragm muscle.

This study only offers a snapshot of the deficits and compensations at one time point in the progression of the disease. It is essential the findings from the study in the dystrophin-deficient mice are confirmed in human DMD patients before its potential applications in these patients can be considered.

David Burns, one of the lead investigators on the study, said:

'Further study of physiological neuromuscular mechanisms that compensate for the absence of dystrophin is needed. A better understanding may provide insight with potential applications to a range of neuromuscular diseases, beyond DMD.'



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Muscular Dystrophy Genetic Testing of Diseases Hyperventilation Rapid Shallow Breathing Symptom Evaluation Dysarthria 

Recommended Reading
Muscular Dystrophy
Overview about muscular dystrophy, a muscle disease characterized by muscle weakness and muscle ......
Age Matters in Regenerating Muscle in Duchenne Muscular Dystrophy
A team of scientists have published details of how a class of drugs called "HDACis" drive ......
Facial Muscle Study Sheds Light on Duchenne Muscular Dystrophy
In patients with neuromuscular disorders, weakness is apparent in the orbicularis oculi , a ...
Dysarthria
Dysarthria is a condition characterized by speech difficulty due to poor or weak speech muscle ......
Genetic Testing of Diseases
Genetic testing helps to confirm a genetic condition in an individual and involves q complex laborat...
Hyperventilation
Hyperventilation occurs when a person breathes in excess to the body’s requirement....
Rapid Shallow Breathing Symptom Evaluation
Rapid shallow breathing / tachypnea is a condition wherein a person takes more breaths per minute th...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use