In micro-preemies, breastfeeding was found to increase levels of metabolites important for brain growth and development, according to sophisticated imaging conducted by an interdisciplinary research team at Children's National.
"Our previous research established that vulnerable preterm infants who are fed breast milk early in life have improved brain growth and neurodevelopmental outcomes. It was unclear what makes breastfeeding so beneficial for newborns' developing brains," says Catherine Limperopoulos, Ph.D., director of MRI Research of the Developing Brain at Children's National. "Proton magnetic resonance spectroscopy, a non-invasive imaging technique that describes the chemical composition of specific brain structures, enables us to measure metabolites essential for growth and answer that lingering question."
According to the Centers for Disease Control and Prevention, about 1 in 10 U.S. infants is born preterm. The Children's research team presented their findings during the Pediatric Academic Societies 2019 Annual Meeting.
Each chemical has its own a unique spectral fingerprint. The team generated light signatures for key metabolites and calculated the quantity of each metabolite. Of note:
Cerebral white matter spectra showed significantly greater levels of inositol (a molecule similar to glucose) for babies fed breast milk, compared with babies fed formula. Cerebellar spectra had significantly greater creatine levels for breastfed babies compared with infants fed formula.
And the percentage of days infants were fed breast milk was associated with significantly greater levels of both creatine and choline, a water soluble nutrient.
"Key metabolite levels ramp up during the times babies' brains experience exponential growth," says Katherine M. Ottolini, the study's lead author. "Creatine facilitates recycling of ATP, the cell's energy currency. Seeing greater quantities of this metabolite denotes more rapid changes and higher cellular maturation. Choline is a marker of cell membrane turnover; when new cells are generated, we see choline levels rise."
Already, Children's National leverages an array of imaging options that describe normal brain growth, which makes it easier to spot when fetal or neonatal brain development goes awry, enabling earlier intervention and more effective treatment.