Breast cancer cells, particularly the aggressive ones, have the ability to modify. That's how they avoid treatment and spread all over the body. But how does a cancer cell get the energy it needs to do this? "We wondered if a cancer cell that wants to change its function can redirect energy not because it takes on new energy but because it has a stored reservoir of potential energy," says Sofia D. Merajver, M.D., Ph.D., professor of internal medicine and epidemiology at the University of Michigan and a researcher at the University of Michigan Rogel Cancer Center.
‘This is an entirely revolutionary way to look at the plasticity of breast cancer cells.’
Read More..Tweet it Now
Merajver's lab looked at levels of glycogen, which represents a stored collection of glucose molecules. Glucose converts to energy, which cancer uses to grow, spread, and metastasize.Read More..
The team measured glycogen levels in cell lines representing triple-negative breast cancer, inflammatory breast cancer, hormone receptor-positive breast cancer, and healthy breast cells.
The study, published in PLOS ONE, found that aggressive cancers stored glycogen in enormous amounts, depending on available oxygen. It's on the order of what's stored in the liver - an organ whose key function is storing glycogen.
"It was surprising just how much glycogen these cancer cells were storing," Merajver says. "This means cancer has that whole amount of glycogen ready to break down into glucose molecules when the need arises."
Even more surprising, the researchers found that an enzyme controlling glycogen degradation in the brain played a key role in glycogen control in breast cancer. The enzyme PYG exists in several forms, including the brain and liver. PYGB is primarily expressed in the brain.
Advertisement
"This is a completely new way to look at the plasticity of breast cancer cells," Merajver says. "We think that this ability to change, for breast cancer cells to rewire themselves depending on their environment, is why many patients become resistant to precision medicines. Our study shows one way the cancer cells do this is by creating a reservoir of building blocks or energy."
Advertisement
Source-Eurekalert