Most common form of breast cancer resists to therapy due to a new genetic change in the estrogen receptor (ER), finds a research team at Magee-Womens Research Institute (MWRI) and UPMC Hillman Cancer Center. The research team also said that recurrent ESR1 fusion proteins have been identified in human breast cancer for the first time and understanding the function of ER gene (ESR1) fusion protein could lead to improved treatments for the disease. The findings are published in the journal Annals of Oncology .
ER-positive breast cancer, diagnosed in two-thirds of breast cancer patients, is fueled by the presence of estrogen in the body. Anti-estrogen therapy is usually successful in treating the disease initially, but ER-positive breast cancers will often recur because tumors develop a resistance to treatment.
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‘Understanding the functions of ER gene (ESR1) fusion proteins will lead to improved treatments for the disease.’
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"We first identified this change in a patient who had ER-positive breast cancer, received anti-estrogen therapy, had her breast cancer recur and eventually passed away from the disease," said senior author Adrian Lee, Ph.D., director of the Women's Cancer Research Center at MWRI and UPMC Hillman Cancer Center, and professor of Pharmacology & Chemical Biology at the University of Pittsburgh. "A member of our lab noticed the mutation while performing posthumous genetic analysis from tissue in our organ donation program, and over time we were able to identify many more cases of this mutation in patients with recurrent disease." This work was performed in collaboration with Foundation Medicine Inc., a genomic testing company that examined ESR1 fusions in close to 10,000 breast cancers sequenced with the FoundationOne CDx test.
According to Lee, ESR1 fusion proteins "outsmart" traditional treatment by splitting in half and eliminating the binding site that anti-estrogen therapy targets.
![Genes Allow Cancer Cells to Resist Drugs]( "Genes Allow Cancer Cells to Resist Drugs")
During chemotherapy, when using certain drugs, the tumor cells are affected by toxic and oxidative stress, which stop their functioning. Gene allow cancer cells to resist drugs
"Physicians will continue administering anti-estrogen therapy, not realizing this genetic mutation has occurred," said Lee. "Now that we understand the change, though, we can detect it with a blood test and help improve treatments for this form of the disease."
According to Lee, genetic analysis will soon be the dominant field of ER-positive breast cancer research, eventually leading to improved treatments and patient outcomes.
"Genomic sequencing is telling us so much about breast cancer. I believe the research we are doing in the laboratory will have a significant clinical impact in the near future, and the work we are doing will play a large part in improving patient care and survival," said Lee.
Source: Eurekalert
Genes Allow Cancer Cells to Resist Drugs
During chemotherapy, when using certain drugs, the tumor cells are affected by toxic and oxidative stress, which stop their functioning. Gene allow cancer cells to resist drugs
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"Physicians will continue administering anti-estrogen therapy, not realizing this genetic mutation has occurred," said Lee. "Now that we understand the change, though, we can detect it with a blood test and help improve treatments for this form of the disease."
According to Lee, genetic analysis will soon be the dominant field of ER-positive breast cancer research, eventually leading to improved treatments and patient outcomes.
"Genomic sequencing is telling us so much about breast cancer. I believe the research we are doing in the laboratory will have a significant clinical impact in the near future, and the work we are doing will play a large part in improving patient care and survival," said Lee.
Source: Eurekalert
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The crab that invades the breast is no more a fear factor with all the advancements that medical science and customized protocols can fight breast cancer. the recent developments in the management of breast cancer.
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 Breast Cancer - Prevention and Management with Lifestyle ChangesLifestyle choices may or may not cause breast cancer but healthy lifestyle changes can open up avenues beyond breast cancer. Good habits will allow one to fight breast cancer and to live with dignity. | Advertisement
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