About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Breast Cancer Risk Prediction Model for African American Women Underestimates Risk

by Kathy Jones on February 18, 2013 at 10:36 PM
Font : A-A+

 Breast Cancer Risk Prediction Model for African American Women Underestimates Risk

Researchers at Boston University's Slone Epidemiology Center (SEC) have found that the prediction model used to detect breast cancer risk among African Americans tends to underestimate the risk in certain subgroups.

The model predicted estrogen receptor (ER)-negative breast cancer, which is a more aggressive form of breast cancer that disproportionately affects African American women, more poorly than ER-positive breast cancer.

Advertisement

The study, published online today in the Journal of the National Cancer Institute, was led by Deborah Boggs, ScD, postdoctoral associate at Slone and the study's corresponding author.

The Breast Cancer Risk Assessment Tool, also known as the Gail model, is used to estimate a woman's breast cancer risk and to determine eligibility for breast cancer prevention trials. The Gail model was developed based on data from white women but has been found to underestimate breast cancer risk in African American women. Researchers had previously modified the Gail model using data from African American women in the Women's Contraceptive and Reproductive Experiences (CARE) study and had validated the CARE model among postmenopausal African American women between the ages of 50 and 79.
Advertisement

In this study, researchers tested the CARE model among both premenopausal and postmenopausal women using data from the Black Women's Health Study (BWHS), an ongoing follow-up study of 59,000 African American women from across the U.S. The investigators focused on 45,942 women who were 30 to 69 years old and free of cancer at the beginning of the study. They found that the CARE model accurately predicted the number of breast cancers that would occur among women who had given birth before the age of 25 but was a less accurate predictor among women who first gave birth at a later age, underestimating the number of breast cancers in this group by 29 percent.

Whereas a woman's age at first birth is used in the Gail model for white women, this factor is not used in the CARE model for African American women. The researchers conclude that age at first birth may be an important factor to include in a risk model for African American women in order to better predict breast cancer risk for women with a later age at first birth.

The authors also found that the CARE model, similar to other breast cancer risk prediction models, is not a reliable tool to predict a woman's individual risk of developing breast cancer. Additionally, it was less effective at predicting, at the individual level, ER-negative breast cancer than ER-positive breast cancer.

The authors conclude that there is a need to develop a better risk model for ER-negative breast cancer, a subtype that is associated with a poorer prognosis than ER-positive tumors and that is more commonly diagnosed in African American women than in white women.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Breast Biopsy Pagets disease of the breast Mastitis Cancer and Homeopathy Breast Cancer Facts Cancer Facts Cancer Tattoos A Body Art Breasts - Structures and Types 

Recommended Reading
Breast Cancer Screening using Mammogram
Breast cancer if detected early can be completely cured. Mammography is used to screen women for ......
Breast Cancer - Prevention and Management with Lifestyle Changes
Lifestyle choices may or may not cause breast cancer but healthy lifestyle changes can open up ......
Breast Cancer Management: Advances
The crab that invades the breast is no more a fear factor with all the advancements that medical ......
Breast Cancer during Pregnancy
Management of breast cancer during pregnancy or pregnancy associated breast cancer requires special ...
Breast Biopsy
Breast biopsy involves removing a sample of breast tissue to determine whether it is cancerous or .....
Breasts - Structures and Types
Different stages of breast development in women and an in-depth look at the breast/bust and its ......
Mastitis
Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the ...
Pagets disease of the breast
A detailed description of the Paget's disease of the breast, characteristic signs and symptoms, dete...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of l...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use