About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Breast Cancer Risk is Not the Same Among Different Progestins Employed in HRT

by Savitha C Muppala on August 13, 2010 at 11:57 PM
Font : A-A+

 Breast Cancer Risk is Not the Same Among Different Progestins Employed in HRT

Researchers found different outcomes on the advancement of breast cancer on comparing four types of progestins used in hormone replacement therapies.

Progestins are used in hormone replacement therapies to counteract the negative effects of estrogen on the uterus and reduce the risk of uterine cancer. However, evidence in recent studies and clinical trials has demonstrated that progestins increase the risk of breast cancer.

Advertisement

But it is now that theUniversity of Missouri researchers have come to the above conclusion.

"Synthetic progestins have different biological effects, due to differences in their structure, stability and how they interact in the body. Clinical use of progestins requires caution. These powerful steroids should only be prescribed when a person has no latent, or dormant, cancer and does not have a family history of cancer. However, it is difficult to diagnose latent tumor cells in women since there are no symptoms," said Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center.
Advertisement

In the study, researchers compared the effects of four clinically relevant progestins on breast cancer tumors in an animal model.

The progestins used in the study were the synthetic progestin medroxporgresterone acetate (MPA), norgesterel (N-EL), norethindrone (N-ONE) and megestrol acetate (MGA). In the United States, most women on hormone replacement therapy are treated with MPA, the progestin in Prempro, said Hyder.

"Although previous studies using an animal model for breast cancer found that MPA functions as a tumor promoter, this study show that N-EL and N-One, when administrated using the same protocol as used for MPA, strongly inhibited tumor development," said Hyder.

"Thus progestins seem to have tumor-stage specific effects, which determine whether these will function as tumor promoters or tumor suppressors. Progestins, such as N-EL and N-ONE, may have potential as preventive agents in women with no history of breast disease or family history of breast cancer. These progestins may also have a preventive role in post-menopausal women who are at an increased risk for developing breast cancer due to ingestion of combined estrogen/progestin (MPA) hormone replacement therapy and may have early stage disease," he added.

The study has been published in the September issue of Cancer Prevention Research from the American Association for Cancer Research.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge on Kidney
World Disability Day 2022 - The Role of Innovative Transformation
Diet and Oral Health: The Sugary Connection May Become Sour
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Breast Biopsy Pagets disease of the breast Mastitis Hot Flash Vaginitis Cancer and Homeopathy Endometrial Cancer Breast Cancer Facts Cancer Facts 

Most Popular on Medindia

Calculate Ideal Weight for Infants Vent Forte (Theophylline) Drug - Food Interactions Blood Pressure Calculator Blood - Sugar Chart Loram (2 mg) (Lorazepam) Sinopril (2mg) (Lacidipine) Iron Intake Calculator The Essence of Yoga Post-Nasal Drip
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Breast Cancer Risk is Not the Same Among Different Progestins Employed in HRT Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests