Women working as a border guard could be at a higher risk of developing breast cancer due to their Air pollution exposure, finds a new study.
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‘Breast cancer preventive genes were found to be suppressed by air pollutants like dioxins and polycyclic aromatic hydrocarbon mostly found In exhaust fumes’
Women working near busy roads are at high risk of developing breast cancer, due to traffic-related air pollution, researchers have warned. The team, from the University of Stirling in Scotland, analyzed the case of a woman who developed breast cancer after spending 20 years working as a border guard at the busiest commercial border crossing in North America.
The woman was one of, at least, five other border guards who developed breast cancer within 30 months of each other and, at another nearby crossing, a cluster of seven other cases were noted.
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"This new research indicates the role of traffic-related air pollution in contributing to the increasing incidence of breast cancer in the general population," Gilbertson said.
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There is a one in 10,000 chance the cases were a coincidence, the study published in the journal New Solutions said because the cancers were all so similar and close together.
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BRCA2 gets rapidly degraded in the presence of aldehydes - also components of exhaust fumes.
"There is much more research to be undertaken," Gilbertson said. "But we now have plausible mechanisms for inferring how the BRCA1/2 tumor suppressors in this highly-exposed border guard became dysfunctional and likely contributed to the ongoing epidemic of sporadic, early onset, premenopausal breast cancer among her colleagues.
"With this new knowledge, industry and government can plan for new designs for industrial and commercial facilities to cut down on the occupational exposures to traffic-related air pollution," Gilbertson said.
Source-IANS
