About Careers Internship MedBlog Contact us

Breast Cancer Mapping Could Become Less Painful With Anaesthetic

by Gopalan on August 9, 2009 at 2:47 PM
Breast Cancer Mapping Could Become Less Painful With Anaesthetic

Breast Cancer mapping Could become less painful With anaesthetic, according to a study released on Thursday.

The sentinel lympth nodes are often the first place breast cancer goes when it spreads, but the biopsy of the nodes is a painful process indeed. Now the anaesthetic route seems to offer a way out.


In Thursday's online issue of Lancet Oncology, U.S. researchers found adding the anesthetic lidocaine reduced injection pain in patients having their sentinel lymph nodes or SLN mapped.

''For centres that use radiocolloid injections for SLN mapping in patients with early breast cancer, the addition of one per cent lidocaine to the radioisotope solution can improve patient comfort, without compromising SLN identification,'' Dr. Alexander Stojadinovic of the United States Military Cancer Institute in Washington and his colleagues concluded in the study.

The researchers set out to test whether adding the anesthetic or adding sodium bicarbonate to adjust the pH of the isotope solution could help reduce pain.

The team enrolled 140 participants with early-stage breast cancer. Of these people, equal numbers, 35, were randomly assigned to receive injections of the radioisotope solution alone (standard care), or the radioisotope combined with either sodium bicarbonate, one per cent lidocaine, or sodium bicarbonate plus lidocaine.

Subjects who were injected with radioisotope alone received four per cent topical lidocaine cream, while those in the three other groups used placebo cream.

The 121 participants who completed the mapping were asked to rate their pain at the time of injection and complete a pain-intensity questionnaire. (The other 19 people were excluded from the analysis either because they declined to participate in the trial, received care elsewhere, there were medical or technical issues with mapping, or unreliable data.)

Average scores on the pain rating scale, with zero representing no pain and 10 the most pain, were:

Standard care group — 6.0

Sodium bicarbonate — 4.7

One per cent lidocaine — 1.6

Sodium bicarbonate plus one per cent lidocaine — 1.6

Average pain rating intensity, which could range from zero to 78, was 17.5 for the standard care group, 15.4 for the sodium bicarbonate group, 4.6 for the one per cent lidocaine group and 3.4 for the sodium bicarbonate plus one per cent lidocaine group.

The SLN identification rate among those who received the lidocaine mixtures were 90 per cent, which was not significantly different than the 96 per cent and 97 per cent rates in the standard care and bicarbonate-only groups, respectively, the researchers said.

Using sodium bicarbonate to make the radioisotope solution less acidic and closer to the physiological pH had little effect on relieving pain, while the lidocaine did.

No adverse events were reported.

''This study is the first of its kind and the authors should be congratulated for addressing an issue which has been widely ignored by the surgical community,'' Hiram Cody, of the Memorial Sloan-Kettering Cancer Center in New York, wrote in a commentary accompanying the study.

''All of us who use [technetium-sulphur] colloid are well advised to add lidocaine to our injection protocols; many patients will benefit.''

Cody also questioned whether all lidocaine solutions used worldwide are equally beneficial, and if changing the volume or site of injection might help.

The study also serves as a reminder that surgery is the most effective therapy for most solid tumours, especially breast cancer, and ''sometimes the smallest and simplest of technical modifications can substantially benefit our patients,'' he concluded.

Source: Medindia
Font : A-A+



Recommended Readings

Latest Cancer News

Personalized Vaccine and T Cell Therapy for Ovarian Cancer Patients
The combination of the personalized cancer vaccine with ACT led to ovarian cancer control in few patients within a span of three months, stated study results.
Kinase-Targeted Therapy Revolutionizes Colorectal Cancer Care
Uncovering key kinases in tumor growth and invasion is crucial for improving targeted therapies in advanced-stage colorectal cancer.
Novel Photo-Oxidation Therapy Holds Promise for Anticancer Treatment
The study findings validate metal-enhanced photo-oxidation for future metal-based anticancer drugs.
Mutations in 11 Genes Linked to Aggressive Prostate Cancer
Mutations in 11 genes are linked to aggressive forms of prostate cancer, which may present novel therapeutic and therapy options.
Link Between Poor Oral Health and Head & Neck Cancer Survival Uncovered
Improved oral health, as indicated by the count of natural teeth and dental appointments preceding the diagnosis, correlated with enhanced head and neck cancer survival rates.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
Greetings! How can I assist you?MediBot

Breast Cancer Mapping Could Become Less Painful With Anaesthetic Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests