BRCA2 Mutations Linked to Childhood Lymphoma Risk

by Colleen Fleiss on  August 4, 2019 at 11:10 AM Cancer News
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Link between BRCA2 gene mutations and potential risk for pediatric or adolescent lymphoma has been identified.
BRCA2 Mutations Linked to Childhood Lymphoma Risk
BRCA2 Mutations Linked to Childhood Lymphoma Risk

The study used whole-genome sequencing data for 1,380 survivors of pediatric or adolescent lymphoma (815 survivors of Hodgkin lymphoma and 565 survivors of non-Hodgkin lymphoma), of which 13 survivors had BRCA2 mutations (five survivors of Hodgkin lymphoma and eight survivors of non-Hodgkin lymphoma).

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Compared with individuals without cancer, there was a statistically significant association between BRCA2 mutations and risk of non-Hodgkin lymphoma but not Hodgkin lymphoma.

Authors: Zhaoming Wang, Ph.D., St. Jude Children's Research Hospital, Memphis, Tennessee, and coauthors

(doi:10.1001/jamaoncol.2019.2203)

Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Source: Eurekalert

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