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BRCA2 Mutations Linked to Childhood Lymphoma Risk

by Colleen Fleiss on August 4, 2019 at 11:10 AM
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BRCA2 Mutations Linked to Childhood Lymphoma Risk

Link between BRCA2 gene mutations and potential risk for pediatric or adolescent lymphoma has been identified.

The study used whole-genome sequencing data for 1,380 survivors of pediatric or adolescent lymphoma (815 survivors of Hodgkin lymphoma and 565 survivors of non-Hodgkin lymphoma), of which 13 survivors had BRCA2 mutations (five survivors of Hodgkin lymphoma and eight survivors of non-Hodgkin lymphoma).

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Compared with individuals without cancer, there was a statistically significant association between BRCA2 mutations and risk of non-Hodgkin lymphoma but not Hodgkin lymphoma.

Authors: Zhaoming Wang, Ph.D., St. Jude Children's Research Hospital, Memphis, Tennessee, and coauthors

(doi:10.1001/jamaoncol.2019.2203)

Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Source: Eurekalert
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