About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Branched Chain Amino Acids and Cardiovascular Disease Linked

by Colleen Fleiss on April 13, 2018 at 1:15 AM
Font : A-A+

Branched Chain Amino Acids and Cardiovascular Disease Linked

Research sheds light on a molecular pathway that heart disease and diabetes share and pointed to a biomarker that is elevated in women at risk of cardiovascular disease and diabetes. The study was conducted by Brigham and Women's Hospital investigators.

The team's results were presented by Deirdre Tobias, ScD, at the AHA Epidemiology and Lifestyle meeting and simultaneously published in Circulation: Genomic and Precision Medicine.

Advertisement


"We examined more than 27,000 women in the Women's Health Study and found that a one-time measurement of branched chain amino acids in the blood stream - a test that now can be easily done - predicted future risk of cardiovascular events to the same extent and independent of LDL cholesterol and other risk factors," said corresponding author Samia Mora, MD, of the Center for Lipid Metabolomics at BWH. "This was particularly so for women who developed type 2 diabetes prior to their cardiovascular disease."

Branched chain amino acids (BCAAs) are thought to play a causal role in the development of insulin resistance and type 2 diabetes. However, few studies have evaluated the association between BCAAs and cardiovascular disease. To investigate, the team measured BCAA levels in blood samples using NMR spectrometry. Of the more than 27,000 women studied, 2,207 experienced a cardiovascular event over the 18 year follow up period.
Advertisement

The team found a positive association between BCAA levels and incident of CVD events. This association was much more pronounced in women who developed diabetes before experiencing a cardiovascular event. The team adjusted for other biomarkers related to diabetes - including hbA1c - finding evidence that BCAAs may be tied to downstream biomarkers of type 2 diabetes metabolism.

"Impaired BCAA metabolism may represent a shared pathway of the metabolic pathophysiology that links the risks of T2D and CVD," the authors conclude. "There is little known at this time as to what leads to elevated levels of BCAAs or what can be done clinically to reduce them, and if this leads to a reduction in risk, but further research will target these important questions," said Tobias.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Sea Buckthorn
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Malnutrition to Obesity - The Big Leap Spirulina Atherosclerosis Alkaptonuria Homocystinuria / Amino Acid Metabolism Disorder 

Recommended Reading
Calculate Your Lifetime Risk of Heart Attack
Heart Risk Calculator assesses the lifetime risk for a heart attack and helps in making the right .....
High Cholesterol
High cholesterol level in blood are a risk for heart disease and stroke. They get deposited in the ....
Foods that Can Save Your Heart
Do you enjoy a glass of wine with your meal? If so it's good news for your heart!...
Foods to Lower Cholesterol and Heart Disease
Heart diseases are the most common and threatening disease today. It has takes millions of lives ......
Atherosclerosis
Atherosclerosis is a condition in which the arteries become hard and narrow, leading to restricted b...
Homocystinuria / Amino Acid Metabolism Disorder
Homocystinuria is a rare inherited condition characterized by increased levels of the amino acid hom...
Malnutrition to Obesity - The Big Leap
Obesity is the root cause of problems like diabetes, heart disease, stroke, arthritis and gall bladd...
Spirulina
Spirulina is a blue-green algae that is grown globally as a health supplement. Of late there is an e...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use