Controlling Cholesterol in Microglia Reduces Chronic Pain
Researchers identified the role of cholesterol in activation of microglia -- immune cells of the spinal cord -- and regulation of chronic pain.
Researchers identified the role of cholesterol in activation of microglia -- immune cells of the spinal cord -- and regulation of chronic pain.
‘Relationship between brain’s immune cells — microglial cells and brain disorders like Alzheimer’s or Parkinson’s disease has been re-emphasized by a new study
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The team analyzed thousands of microglia from different brain regions of deceased patients who had been diagnosed with a variety of neuropsychiatric and neurodegenerative disorders, using advanced genomic techniques. The study also identified two new genes that may be associated with brain disorders — the USP6NL gene (associated with Alzheimer’s disease) and the P2RY12 gene (associated with Parkinson’s disease).
The study thereby highlights the critical role of microglia in certain brain diseases at different stages of life, which may further serve as a potential guide for future studies.
Dying Neurons Control Eating Behaviors of the Brain Microglia
Microglia clearance activity in different brain regions goes hand in hand with the natural rate of neuronal degeneration/death and can play a role in neurodegenerative diseases.
Microglia clearance activity in different brain regions goes hand in hand with the natural rate of neuronal degeneration/death and can play a role in neurodegenerative diseases.
Dysfunctional Microglia Cells Contribute to the Loss of Synapses in Alzheimer's
Scientists continue to unravel the complex brain changes involved in the onset and progression of Alzheimer’s disease.
Scientists continue to unravel the complex brain changes involved in the onset and progression of Alzheimer’s disease.
Sex Differences in Brain Microglia Alter Response to Pain Therapies
A female brain's resident immune cells are more active in regions involved in pain processing relative to males.
A female brain's resident immune cells are more active in regions involved in pain processing relative to males.
