About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Brain Tumour Size may Be Reduced by Drugs Used to Inhibit Blood Vessel Growth

by Rajashri on August 25, 2008 at 4:03 PM
 Brain Tumour Size may Be Reduced by Drugs Used to Inhibit Blood Vessel Growth

Drugs used to inhibit a specific fatty acid in brains with glioblastoma-like tumours not only reduced new blood vessel growth and tumour size dramatically, but also prolonged survival, according to a study on mice by researchers at the Medical College of Wisconsin in Milwaukee.

"These rat model tumours were developed from human glioblastoma tumour cells and closely mimic human tumours in growth patterns and response to therapy," said lead researcher David Harder, Ph.D., Kohler Co. Professor in Cardiovascular Research.

Advertisement

"The concept of targeting blood vessels that feed tumours as an approach to limit tumour growth is not a novel idea. However, blocking the specific fatty acid described in this study is novel, and holds great promise for use in humans," he added.

Previous studies from the Harder lab have shown that specific fatty acids generated in the brain induce new blood vessel growth known as angiogenesis.
Advertisement

Harder and colleagues designed these studies on the premise that all cells, including cancer cells, require oxygen for growth and that blocking formation of specific fatty acids would decrease blood vessel growth and oxygen supply to tumours, retarding their growth.

In the new study, they compared three sets of rats with induced tumours, two groups using either one of two inhibitor drugs, 17-ODYA or miconazole, to block the fatty acid CYP epoxygenase and a control group, receiving a placebo.

Drugs were infused directly into the tumours over an extended period of time, using specially designed miniature osmotic pumps and a very small burr hole in the skull. The pumps, similar to those used in humans, were buried just beneath the skin through a tiny incision.

Researchers found that as compared to the control group, tumour size in the drug-infused groups was reduced by an average 50 to 70 percent, and survival time increased by five to seven days, equivalent to three to four months in terms of human survival.

"These pumps have been used in humans for other diseases and can be designed for delivery of these drugs as well. We believe they can be used to deliver drugs to block angiogenesis in complex human tumours such as glioblastomas," Harder said.

The study is published in the August 2008 Journal of Cerebral Blood Flow and Metabolism.

Source: ANI
RAS/L
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Drug News

Projected Growth: Psychedelic Drug Market Anticipated to Hit $7.2 Billion by 2029
The psychedelic market set for remarkable growth, projected to hit $7.2B by 2029 with a strong 55% CAGR.
Promising ALS Drug Candidate Extends Lifespan
The study explores whether CDNF could influence the progression of ALS in rodent models and to elucidate the mechanism through which it operates.
Amoxicillin-Calvulanate Vs Amoxicillin Preference in Child Sinusitis Treatment
Amoxicillin-clavulanate use in acute sinusitis patients is associated with a higher incidence of adverse events.
ADHD Medication Errors Surge by Nearly 300%
Professionals advocate for enhanced education of patients and caregivers, and creation of more effective child-resistant systems for monitoring ADHD medication.
Unknown Medication Side Effects Reported by 52% of Indian Families
In June, WHO raised concerns about 7 Indian cough syrups after complaints from several countries about contamination and health issues.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
MediBotMediBot
Greetings! How can I assist you?MediBot
×

Brain Tumour Size may Be Reduced by Drugs Used to Inhibit Blood Vessel Growth Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests