‘By reducing the excitability (ability to activate easily) of the brain hemispheres responsible for increasing negative emotion, brain stimulation can have antidepressant effects.’
In depression, processing of emotion is disrupted in the frontal region of both the left and right brain hemispheres also known as the dorsolateral prefrontal cortices (dlPFC). The disruptions are thought to be the root of increased negative emotion and diminished positive emotion in disorder
Using magnetic stimulation outside the brain, the rTMS technique researchers at University of Münster, Germany, show that, despite the use of inhibitory stimulation currently used to treat depression, excitatory stimulation better reduced a person's response to fearful images.
The findings provide the first support for an idea that clinicians use to guide treatment in depression, but has never been verified in a lab. "This study confirms that modulating the frontal region of the brain, in the right hemisphere, directly effects the regulation of processing of emotional information in the brain in a 'top-down' manner," said Cameron Carter, M.D., Editor of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.
Referring to the function of this region as a control center for the emotion-generating structures of the brain. "These results highlight and expand the scope of the potential therapeutic applications of rTMS," said Dr. Carter.
Reducing excitability of the right dlPFC using inhibitory magnetic stimulation has been shown to have antidepressant effects
, even though it's based on an idea--that this might reduce processing of negative emotion in depression--that has yet to be fully tested in humans.
Co-first authors Swantje Notzon, M.D., and Christian Steinberg, Ph.D., and colleagues divided 41 healthy participants into two groups to compare the effects of a single-session of excitatory or inhibitory magnetic stimulation of the right dlPFC. They performed rTMS while the participants viewed images of fearful faces to evoke negative emotion or neutral faces for comparison.
Excitatory and inhibitory rTMS had opposite effects--excitatory reduced visual sensory processing of fearful faces, whereas inhibitory increased visual sensory processing. Similarly, excitatory rTMS reduced participants' reaction times to respond to fearful faces and reduced feelings of emotional arousal to fearful faces, which were both increased by inhibitory rTMS.
Although the study was limited to healthy participants, senior author Markus Junghöfer, Ph.D., notes that "...these results should encourage more research on the mechanisms of excitatory and inhibitory magnetic stimulation of the right dlPFC in the treatment of depression."