About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Brain Hormone Linked to Socially Isolated People’s Anxiety, Aggression

by VR Sreeraman on November 15, 2007 at 6:07 PM
Font : A-A+

Brain Hormone Linked to Socially Isolated People’s Anxiety, Aggression

A study on mice has shown that altered levels of an enzyme that controls production of a brain hormone may be the reason why socially isolated people are anxious and aggressive.

The study was conducted by researchers at the University of Illinois at Chicago College of Medicine who based their study on previous studies that had suggested that the neural pathways that underlie aggression, anxiety and fear include activation of specific types of neural circuitry that leads into the amygdala, the region of the brain responsible for emotion.

Advertisement

The researchers looked in these types of neurons for changes in the levels of two enzymes that are needed for the production of allopregnanolone, a brain hormone that acts to reduce stress through regulation of GABA, an important neurotransmitter.

They found that the level of one of the enzymes, called 5-alpha-reductase type I, was reduced nearly 50 percent in the lonesome mice. Levels of the other enzyme did not change.
Advertisement

The researchers suggest that the decrease of 5-alpha-reductase type I and the consequent reduction in the hormone may impair the function of circuits leading to the amygdala and explain the aggressive behaviour, perhaps related to anxiety, in socially isolated mice.

"We use this animal model for human stress because social isolation in both animals and humans can be responsible for a range of psychological effects, including anxiety, aggression and memory impairment," said Dr. Erminio Costa, director of the UIC Psychiatric Institute, professor of biochemistry and one of the authors of the study.

The study is important from the angle of humans as people respond to stress in similar ways as mice. "Humans respond to similar stress in very similar ways. By identifying the mechanism we may be able to identify drugs that can treat these effects of stress," said Dr. Alessandro Guidotti, UIC scientific director and professor of biochemistry in psychiatry.

UIC researchers Roberto Agis-Balboa, Dr. Graziano Pinna, Fabio Pibiri and Dr. Bashkim Kadriu also contributed to the study. The work was supported by grants from the National Institute of Mental Health.

The study is reported in this week's online addition of the Proceedings of the National Academy of Sciences.

Source: ANI
LIN/P
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First Dose of COVID-19 Vaccines May Improve Mental Health
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Parkinsons Disease Surgical Treatment Asperger´s Syndrome Stress Relief Through Alternative Medicine Brain Brain Facts Hyperventilation Ataxia Language Areas in The Brain Ways to Improve your Intelligence Quotient (IQ) 

Recommended Reading
Brain Depression - Animation
Interactive section of Medindia provides information about chemistry of Brain depression...
Scientist Found New Mechanism for Brain Learning
A study of mice by researchers at UT Southwestern Medical Center has revealed a new mechanism of ......
Asperger´s Syndrome
Asperger’s Syndrome or (AS) is a neurological condition marked by delay in the development of motor ...
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Hyperventilation
Hyperventilation occurs when a person breathes in excess to the body’s requirement....
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Ways to Improve your Intelligence Quotient (IQ)
Intelligence quotient (IQ) is a psychological measure of human intelligence. Regular physical and me...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use