The underlying cause of Alzheimer's disease are not fully understood, but still a good deal of evidence points to the accumulation of several proteins have come under light. ‚-amyloid, a protein that's toxic to nerve cells is formed by the activity of several enzymes, including one called BACE1.
Most Alzheimer's disease patients have elevated levels of BACE1, which in turn leads to more brain-damaging ‚-amyloid protein. In a paper published August 15 in The Journal of Neuroscience, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) found that BACE1 does more than just help produce ‚-amyloidóit also regulates another cellular process that contributes to memory loss. This means that just inhibiting BACE1's enzymatic activity as a means to prevent or treat Alzheimer's disease isn't enoughóresearchers will have to prevent cells from making it at all.
"Memory loss is a big problemónot just in Alzheimer's disease, but also in the normal aging population," said Huaxi Xu, Ph.D., professor in Sanford-Burnham's Del E. Webb Neuroscience, Aging, and Stem Cell Research Center and senior author of the study. "In this study, we wanted to better understand how BACE1 plays a role in memory loss, apart from ‚-amyloid production."