Increasing the activity of the habenula, led to social problems in rodents, whereas decreasing activity of the region prevented social problems.
A new study by researchers at Roche in Basel, Switzerland has identified a key brain region of the neural circuit that controls social behavior.
Commonalities Found in Brains of People With Huntington’s and Parkinson’s
Most of the genes perturbed in brains from both Huntington's disease (HD) and Parkinson's disease are related to the same immune response and inflammatory pathways.
Advertisement
‘Understanding how altered brain function leads to social deficits could help develop novel targeted therapeutics for autism spectrum disorder.’
Tweet it Now
The study, which appears in Biological Psychiatry, suggests that social impairments characteristic of autism spectrum disorder may stem from alteration of activity in this circuit, and that tuning this circuit may help treat the social deficits in the disorder.
"We are excited about this study as it identifies a brain circuit that may play a critical role in social reward, which is affected in autism," said senior author Dr. Anirvan Ghosh, who was the Head of Neuroscience Research at Roche and now serves as Head of Research and Early Development at Biogen. The findings provide clues as to what may be altered in the brain to lead to neurodevelopmental conditions like autism spectrum disorder.
![Strong Correlation Between Hyperactive Brain Activity and Chronic Pain]( "Strong Correlation Between Hyperactive Brain Activity and Chronic Pain")
Hypersensitivity experienced by chronic pain patients may result from hyperactive brain networks.
Previous research has linked social function to the prefrontal region of the brain, but circuits that affect prefrontal control of social behavior were unknown. So first author Dr. Madhurima Benekareddy and colleagues activated the prefrontal region in mice and rats, and performed a brain-wide screen to find which regions responded. The screen identified changes in activity in regions related to emotional behavior, particularly in the habenula.
In the study, the researchers then used a combination of different techniques to map the connections from the habenula to the frontal area of the brain, and to precisely control the activity of neurons in these regions. Turning up the activity of neurons in the habenula reduced how much the rats and mice socialized. Turning down habenula activity prevented the social deficits that could be induced by activating the frontal region.
According to the authors, an alteration of the normal activity range for the circuit may cause behavioral function in disorders such as autism spectrum disorder. "Understanding how altered brain function leads to social deficits could help develop novel targeted therapeutics for autism spectrum disorder," said Ghosh, such as by tuning the circuit to correct the altered activity.
The findings also have implications for diseases other than autism spectrum disorder, including schizophrenia and depression. The circuit incorporates brain regions involved in reward and pleasure, leading the authors to consider that social dysfunction may stem from reduced enjoyment in social interaction. "It is interesting that the circuit implicated in social behavior in this study is also a circuit implicated in the biology of depression," said Dr. John Krystal, Editor of Biological Psychiatry. "Perhaps this circuit represents a pathway through which disruptions in social relationships contribute to negative mood states and depression."
Source: Eurekalert
Strong Correlation Between Hyperactive Brain Activity and Chronic Pain
Hypersensitivity experienced by chronic pain patients may result from hyperactive brain networks.
Advertisement
Previous research has linked social function to the prefrontal region of the brain, but circuits that affect prefrontal control of social behavior were unknown. So first author Dr. Madhurima Benekareddy and colleagues activated the prefrontal region in mice and rats, and performed a brain-wide screen to find which regions responded. The screen identified changes in activity in regions related to emotional behavior, particularly in the habenula.
In the study, the researchers then used a combination of different techniques to map the connections from the habenula to the frontal area of the brain, and to precisely control the activity of neurons in these regions. Turning up the activity of neurons in the habenula reduced how much the rats and mice socialized. Turning down habenula activity prevented the social deficits that could be induced by activating the frontal region.
According to the authors, an alteration of the normal activity range for the circuit may cause behavioral function in disorders such as autism spectrum disorder. "Understanding how altered brain function leads to social deficits could help develop novel targeted therapeutics for autism spectrum disorder," said Ghosh, such as by tuning the circuit to correct the altered activity.
The findings also have implications for diseases other than autism spectrum disorder, including schizophrenia and depression. The circuit incorporates brain regions involved in reward and pleasure, leading the authors to consider that social dysfunction may stem from reduced enjoyment in social interaction. "It is interesting that the circuit implicated in social behavior in this study is also a circuit implicated in the biology of depression," said Dr. John Krystal, Editor of Biological Psychiatry. "Perhaps this circuit represents a pathway through which disruptions in social relationships contribute to negative mood states and depression."
Source: Eurekalert
Brain-Cell 'Antenna' Key to Understanding Obesity
Brain's ability to regulate body weight depends on a novel form of signaling in the brain's hunger circuit via antenna-like structures on neurons.
Advertisement
 Parkinson’s Disease Shows Changes in BrainstemChanging mitochondrial DNA in the pedunculopontine cholinergic neurons can be possible targets for the treatment of Parkinson's. | Advertisement
|
Advertisement
Recommended Readings
Latest Research News
Ae. aegypti mosquitoes are carriers of "arthropod-borne" or "arbo-" viruses, which encompass the dengue virus, yellow fever virus, Zika virus, and chikungunya virus.
Cerebrospinal fluid (CSF) leaks are detected in approximately 1-3% of adults who have experienced a traumatic brain injury.
The optogenetic activation of hippocampal astrocytes can be viewed as a novel therapeutic avenue for addressing Alzheimer's disease.
In Alzheimer's disease condition, the control and adjustment of ABCA7 levels in response to inflammation and the decrease in the availability of cholesterol.
Atopic dermatitis (AD) and inflammatory bowel disease (IBD) can lead to alterations in the microbiome, and disruptions in the skin and gut barrier.
