Medindia
Advertisement

Brain Chemical Dopamine Plays a Role in Promoting Chronic Pain

by Dr. Trupti Shirole on May 8, 2015 at 8:03 AM
Font : A-A+

Brain Chemical Dopamine Plays a Role in Promoting Chronic Pain

Dopamine is a neurotransmitter that helps to control the brain's reward and pleasure centers. It also helps regulate movement and emotional responses, and it enables us not only to see rewards, but to take action to move toward them. The findings of a new study suggest that dopamine plays a role in promoting chronic pain. Ted Price, associate professor at the University of Texas at Dallas, said, "These findings demonstrate a novel role for how dopamine contributes to maintaining chronic pain states. This may open up new opportunities to target medicines that could reverse chronic pain."

The researchers studied the sequence of pain impulses traveling from the brain to the spinal cord in mice. They found that by removing a collection of neurons called A11 that contain the brain chemical dopamine, chronic pain was selectively diminished.

Advertisement

Pain signals travel from an injury to the spinal cord where they pass on electrical or chemical pain signals to other cells. Those pain signals then travel upward and relay this information to neurons in the brain where they can be distributed throughout. There is no single pain center in the brain, but there is substantial evidence that chronic pain changes how these pain centers are activated.

Among people with chronic pain, neurons continue to send pain signals to the brain, even in the absence of injury, but the causes of this are not known. A potential explanation comes from A11 neurons. These neurons did not affect acute pain, but they did had a profound effect on chronic pain. By targeting these neurons in mice with chronic pain, the researchers could permanently reverse a chronic pain state.

The study is published in The Journal of Neuroscience.

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Sedentary Behavior Precipitates Night-Time Hot Flashes
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Parkinsons Disease Surgical Treatment Brain Brain Facts Amyotrophic Lateral Sclerosis (ALS) Ataxia Thoracic Outlet Syndrome Language Areas in The Brain Ways to Improve your Intelligence Quotient (IQ) 

Recommended Reading
Vitamin D: A Possible Solution to Chronic Pain
Chronic pain may be resolved by taking vitamin D treatment, even when pain management pills do not ....
Study Reveals How Brain Perpetuates Chronic Pain
Two molecules involved in perpetuating chronic pain in mice have been pinpointed by scientists....
New Target for Chronic Pain Treatment Identified
A novel target for treating chronic pain: an enzyme called PIP5K1C has been discovered by UNC ......
Amyotrophic Lateral Sclerosis (ALS)
Find out more about the degenerative disease- Amyotrophic lateral sclerosis....
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Thoracic Outlet Syndrome
Thoracic outlet syndrome (TOS) is a rare condition that occurs when blood vessels or nerves become c...
Ways to Improve your Intelligence Quotient (IQ)
Intelligence quotient (IQ) is a psychological measure of human intelligence. Regular physical and me...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use