Lostartan - a drug widely used to treat high blood pressure reduced cigarette smoke-induced lung disease in mice, shows study.

COPD is among the most common causes of death in the US. It is a smoking-related disease for which there are currently no disease-altering therapies.
Losartan blocks the protein angiotensin receptor type 1, and its effects on cigarette smoke-induced lung injury were a result of the fact that blocking angiotensin receptor type 1 leads to a decrease in levels of the soluble molecule TGF-beta.
The authors therefore suggested that other TGF-beta-targeted therapeutics might also be viable candidates for the treatment of COPD.
Source-ANI