University of California's experimental study found that treatment with botulinum toxin type B (BoNT-B) produces lasting reduction in abnormal pain responses caused by physical nerve injury or chemotherapy-related nerve damage in mice.
The study shows differing effects of local versus spinal injection of botulinum toxin and lends new insights into the molecular-level explanations for how "Botox" works to affect pain processing.
Since botulinum toxin causes temporary muscle paralysis, the pain-reducing effects have been attributed to muscle relaxation.
However, recent studies have suggested that other analgesic mechanisms may be operating as well.
Cellular-level studies showed that the two types of BoNT-B injection had differing effects in the pain-processing centers of the spinal cord.
The results provided new insights into the specific molecular targets involved in local and intrathecal injection.
The study is published in Anesthesia & Analgesia.
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