Botulinum toxin, commonly known as Botox could offer an effective new treatment for two forms of neuropathy, pain caused by different types of nerve injury, says a new study.
University of California's experimental study found that treatment with botulinum toxin type B (BoNT-B) produces lasting reduction in abnormal pain responses caused by physical nerve injury or chemotherapy-related nerve damage in mice.
Botox
Botox injections, the fastest growing cosmetic procedures, are considered as the ultimate fountain of eternal youth.
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The study shows differing effects of local versus spinal injection of botulinum toxin and lends new insights into the molecular-level explanations for how "Botox" works to affect pain processing.
Botulinum toxin is most familiar from the use of BoNT-A, commonly known by the trade name Botox, for cosmetic plastic surgery. Both BoNT-A and BoNT-B are used for treatment of various neuromuscular disorders. Over the past decade, BoNT-A has been successfully used to treat certain chronic pain syndromes.
![Botox Helps NIH Identify New Role of Molecules Used by Nerve Cells in Brain]( "Botox Helps NIH Identify New Role of Molecules Used by Nerve Cells in Brain")
Botox has proven to be a valuable agent for researchers at National Institutes of Health who have used the anti-aging agent to identify a new and important role for a group of molecules.
Since botulinum toxin causes temporary muscle paralysis, the pain-reducing effects have been attributed to muscle relaxation.
However, recent studies have suggested that other analgesic mechanisms may be operating as well.
Cellular-level studies showed that the two types of BoNT-B injection had differing effects in the pain-processing centers of the spinal cord.
The results provided new insights into the specific molecular targets involved in local and intrathecal injection.
The study is published in Anesthesia & Analgesia.
Source: ANI
Botox Helps NIH Identify New Role of Molecules Used by Nerve Cells in Brain
Botox has proven to be a valuable agent for researchers at National Institutes of Health who have used the anti-aging agent to identify a new and important role for a group of molecules.
Advertisement
Since botulinum toxin causes temporary muscle paralysis, the pain-reducing effects have been attributed to muscle relaxation.
However, recent studies have suggested that other analgesic mechanisms may be operating as well.
Cellular-level studies showed that the two types of BoNT-B injection had differing effects in the pain-processing centers of the spinal cord.
The results provided new insights into the specific molecular targets involved in local and intrathecal injection.
The study is published in Anesthesia & Analgesia.
Source: ANI
Toxic Botox Travels at High Speed Through Our Nerves to the Central Nervous System
The discovery that Botox can travel through our nerves is worrying because this pathway is also hijacked by other pathogens such as West Nile or rabies viruses.
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 Regular Use of Botox Increases Risk of ResistanceThe human body develops resistance to Botox over time and the beauty treatment may stop working altogether after a few years. | Advertisement
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