Bone Marrow Cells Promote Tumor Growth in Lung Cancer

by Hannah Joy on  December 28, 2017 at 11:36 AM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

A certain type of cell in the bone marrow known as osteocalcin-expressing (Ocn+) osteoblasts, aid in the progression of tumor in patients with early stage lung cancer, reveals a new study.
Bone Marrow Cells Promote Tumor Growth in Lung Cancer
Bone Marrow Cells Promote Tumor Growth in Lung Cancer

Bone marrow derived cells have been shown to contribute to tumor progression, though many of the specific mechanisms through which this occurs remain unknown.

Here, Camilla Engblom et al. found that mice with lung tumors had a significantly higher bone mass than their healthy counterparts, a pattern that was also seen in lung cancer patients.

A closer look within the bone marrow of the tumor-bearing mice revealed a high number of osteocalcin-expressing (Ocn+) osteoblasts, cells that participate in bone formation. Intriguingly, deletion of Ocn+ cells suppressed tumor growth, indicating that these Ocn+ cells are functionally required for lung cancer progression.

The authors next discovered that these Ocn+ cells stimulate production of a certain type of neutrophil that infiltrates the lung tumors.

These neutrophils exhibited increased expression of genes associated with tumor-promoting processes, including angiogenesis, suppression of T cell responses, and tumor cell proliferation and growth, the authors report.

They note that, in a small study of patients with lung cancer, the same neutrophil signature correlated with worse patient survival.

This research is highlighted in a Perspective by Haiying Zhang and David Lyden.



Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

More News on:

Bone Marrow Aspiration and Biopsy Lung Biopsy Lung Cancer Leucopenia / Leukopenia Infantile Cortical Hyperostosis Cancer and Homeopathy Parkinsons Disease Surgical Treatment Hodgkins Lymphoma Non-Hodgkins Lymphoma Cancer Facts 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive