Bone Fluoride Levels Not Associated With Osteosarcoma

by Kathy Jones on  July 30, 2011 at 7:06 PM Cancer News
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A study that investigated bone fluoride levels in individuals with osteosarcoma, which is a rare, primary malignant bone tumor that is more prevalent in males has been released by the International and American Associations for Dental Research have released in its Journal of Dental Research.
 Bone Fluoride Levels Not Associated With Osteosarcoma
Bone Fluoride Levels Not Associated With Osteosarcoma

Since there has been controversy as to whether there is an association between fluoride and risk for osteosarcoma, the purpose of this study, titled "An Assessment of Bone Fluoride and Osteosarcoma," was to determine if bone fluoride levels were higher in individuals with osteosarcoma.

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No significant association between bone fluoride levels and osteosarcoma risk was detected in this case-control study, based on controls with other tumor diagnoses.

In the case-control study, by lead researcher Chester Douglass of Harvard University, patients were identified by physicians in the orthopedic departments from nine hospitals across the U.S. between 1993 and 2000. In this report, the study sample included incident cases of primary osteosarcoma and a control group of patients with newly-diagnosed malignant bone tumors. Specimens of tumor-adjacent bone and iliac crest bone were analyzed for fluoride content. The study was approved by the Institutional Review Boards of the respective hospitals, Harvard Medical School and the Medical College of Georgia.

Logistic regression of the incident cases of osteosarcoma (N=137) and tumor controls (N=51), adjusting for age and sex and potential confounders of osteosarcoma, was used to estimate odds ratios (OR) and 95% confidence intervals (CI). There was no significant difference in bone fluoride levels between cases and controls. The OR adjusted for age, gender, a history of broken bones was 1.33 (95% CI: 0.56-3.15).

"The controversy over whether there is an association between fluoride and risk for osteosarcoma has existed since an inconclusive animal study 20 years ago," said IADR Vice-president Helen Whelton. "Numerous human descriptive and case-control studies have attempted to address the controversy, but this study of using actual bone fluoride concentrations as a direct indicator of fluoride exposure represents our best science to date and shows no association between fluoride in bone and osteosarcoma risk."

Source: Eurekalert

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Lead author, dentist Chester Douglass "has written reviews of the literature for several companies that sell, reimburse for, or do research on preventive dentistry products, most notably GlaxoSmithKline, Colgate-Palmolive, Dentsply, Quintile, Delta Dental Plans " according to the acknowledgment section of this study. C Hayes [co-author] "has done limited consulting with Procter and Gamble." This study has some major flaws and it seems, in my opinion, that the researchers did their best to have the outcome align with their predetermined beliefs. Here are three: 1) The controls had bone cancer also that could have been fluoride-induced (co-author, Hoover found Ewings Sarcoma in a previous fluoride study) 2) The Controls were much older than the Cases. Median age 41 and 17.6 years-old, respectively (Fluoride builds up in bone with age so this is a gross dissimilarity) 3) Osteosarcoma occurs more frequently in teenage boys. There were less than 20 controls under age 20 used in Douglass' analysis. 73 of the total cases were male and 36 of the controls were male Douglass promised that his study would be larger than that of Elise Bassin, his PhD student who found an association between fluoride and osteosarcoma; but actually Douglass' study is much smaller. This study adds nothing new. Why are dentists doing cancer research anyway? The International Association of Dental Research (IADR) fiercely protects and encourages fluoridation. The Journal of Dental Research is the IADR’s flagship publication


More News on:

Tooth Decay Infantile Cortical Hyperostosis Tooth Discoloration Osteosarcoma Renal Osteodystrophy / Mineral Bone Disorder Fluorosis 

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