Blood Marker Determines the Delivery of Cetuximab Drug for Colon Cancer

Patients with colorectal cancer who can benefit from receiving the drug cetuximab can be determined with the help of a biomarker in blood.

The research, published in the Clinical Cancer Research, a journal of the American Association for Cancer Research, solves one of the mysteries of why receiving cetuximab was futile for up to half of incurable colorectal cancer patients who did not respond to treatment, says principal investigator Dr. Geoffrey Liu, clinician-scientist at Princess Margaret Cancer Center, University Health Network, in collaboration with the Canadian Cancer Trials Group and the Australasian Gastro-Intestinal Trials Group.

Increasing Access to Colon Cancer Screening Through Medicare Could Save Many Lives in the US
Sixty three percent of colon cancer deaths in 2010 could have been prevented if patients had been screened through medicare.

‘Blood marker FCGR2A identifies the colorectal cancer patients who will benefit from taking the drug cetuximab. ’

Tweet it Now

Dr. Liu holds the Alan B. Brown Chair in Molecular Genomics and is Associate Professor of Medicine, Medical Biophysics, and Epidemiology, Dalla Lana School of Public Health, University of Toronto. "Our research discovered that the blood marker FCGR2A identifies a new group of patients that will benefit from taking cetuximab. With this finding, we believe we are now on the way to move it into the clinical setting to provide patients targeted, effective treatment," said Dr. Liu.

"In a group of metastatic colorectal cancer patients who were running out of treatment options, the previous clinical trial determined that cetuximab was most effective in a certain group of patients with tumors carrying a RAS mutation. But it certainly didn''t work for everyone and so the race was on to find out how to better identify which patients would benefit from this drug," says Dr. Liu.

"Our finding, which resulted from analyzing archived tumor and normal tissue samples from some of the 572 patients enrolled in that trial, further refines this quest and defines another subset of patients who will respond to the drug.

Inflammation in the Gut Increases Risk of Colon Cancer
A quarter of the world's population is affected by some type of gut inflammation and these patients have a much higher chance of developing colon cancer.

"We need to find other ways to personalize cancer medicine for people with colorectal disease, keeping in mind that cetuximab is an expensive drug and can have side effects."

"So instead of looking at aspects in the tumor, which is where RAS mutations show up, we looked at certain things in the blood and normal tissues that we could measure for heritable genetic variations."

Latest Progress in Precision Prevention of Colorectal Cancer
Research groups debuted their latest progress in precision prevention to predict the risk of colorectal cancer that integrates genetic, lifestyle and environmental risk factors.

Dr. Liu, a medical oncologist who specializes in lung cancer, describes the pathway to today's discovery as an ideal example of what can happen when you follow the drug and wherever the research may lead.

"When we followed the drug, first in lung cancer and then in other cancers, it led us to colorectal cancer where the drug was also being used, and directly onto this new finding."

Exposure to Triclocarban During Pregnancy Disrupts Offspring's Gut Microbiota
Use of a common nonprescription antimicrobial, triclocarban (TCC), during pregnancy and breast-feeding may alter the offspring's composition of intestinal bacteria.

Source-Newswise