About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Biomarker Used to Detect Acute Kidney Injury Just Got Better

by Dr. Enozia Vakil on September 6, 2013 at 8:47 PM
Font : A-A+

 Biomarker Used to Detect Acute Kidney Injury Just Got Better

A biomarker, originally developed to identify early acute kidney injury after a surgery can now help detect the same in emergency room patients too.. In a study published online Sept. 5 in the Clinical Journal of the American Society of Nephrology, the findings expand the overall utility and potential medical settings for using the test, according to researchers.

The test measures the protein neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of early AKI. It was invented by researchers at Cincinnati Children's Hospital Medical Center to detect AKI earlier than existing methods, and to more promptly begin treatment. "The majority of our studies on NGAL have been performed in well controlled settings of hospital-acquired AKI, such as cardiac surgery, contrast administration or other critically ill patients," said Prasad Devarajan, MD, senior author and director of Nephrology and Hypertension at Cincinnati Children's.

Advertisement

"The purpose of this study was to determine the biomarker's accuracy in a diverse group of patients admitted from the emergency department, where patients with early signs of AKI are often misdiagnosed." The study involved patients admitted through the emergency room of Fernando Fonseca Hospital in Portugal, which also closely collaborated on the study. The findings demonstrate the NGAL test, which uses a single drop of blood and provides results within 15 minutes, was able to accurately distinguish AKI from reversible transient kidney dysfunction. Of 616 patients who participated in the study, individuals who were subsequently diagnosed with true AKI had the highest levels of NGAL detected at the time of hospital admission. The study also identified a cutoff point in NGAL levels above which the risk of acute kidney injury increases tenfold.

Results of a study previously published in 2008 by Devarajan showed that the NGAL test predicted AKI in pediatric heart surgery patients within hours instead of days, allowing treatment that prevented serious damage to kidneys. Prior to the NGAL test, serum creatinine was the only reliable method for detecting kidney damage; however, the long wait for results often resulted in permanent kidney damage.
Advertisement

With a growing number of patients coming to emergency rooms with community-acquired AKI, Devarajan says having a rapid, reliable method of detecting kidney injury is increasingly important. "This latest study showed that this simple laboratory test provides an accurate prediction of acute kidney injury and its severity in a diverse clinical setting," said Devarajan. "The identification of biomarkers that differentiate intrinsic AKI from transient reversible forms of renal dysfunction and predict outcomes is a high priority."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Athletes Foot Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Urology Paediatric Emergencies Cysts and Tumours Kidney Disease Kidney Kidney Health Stones in Urinary Tract 

Recommended Reading
In African Americans, Socioeconomic Status is a Significant Barrier to Living Kidney Donation
A study says that socioeconomic status is a more important barrier to living kidney donation than .....
Athletes Foot
Athlete’s foot (tinea pedis/ringworm of the foot) is a fungal infection of the feet....
Cysts and Tumours
Ultrasound scan reveals multiple cysts and there is no function on that kidney when tested on DMSA s...
Hydronephrosis / Antenatal Counseling
Currently most pregnant women undergo one or two ultrasound scans during their pregnancy....
Stones in Urinary Tract
Ask people who have suffered from urinary stones and they will tell you how excruciating the pain ca...
Urinary Stones In Children
There is a wide misconception that only adults develop stones. On the contrary kidney stones are ver...
Urology Paediatric Emergencies
The testis can go for a twist inside the sac it is held. This results in loss of blood supply. If le...
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. Abn...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use