Men with glioblastoma may have worse survival due to neuroinflammation protein as per a study “The Translocator Protein (TSPO) Genetic Polymorphism A147T Is Associated with Worse Survival in Male Glioblastoma Patients”, at the Florida International University, published in the special issue of the Cancers journal. Glioblastoma is one of the deadliest and devastating types of brain tumors that affect glial cells of the brain. It burdens around 12,000 people in the U.S. annually with males being affected almost 1.6 times more than females.
‘Study finds that men with glioblastoma may have worse survival due to a neuroinflammation protein called translocator protein 18 kDa (TSPO). This may help formulate the protein as a biomarker in the prognosis of these tumors.
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The median survival time for glioblastoma is 12 to 14 months, and less than 7% of patients survive more than five years. This mandates better treatments and strategies for the disease. One of the widely used biomarkers of neuroinflammation is a specific protein called translocator protein 18 kDa (TSPO). The study shows that there is a connection between TSPO and worse survival outcomes in male glioblastoma patients.
“I've studied TSPO for more than 20 years and knew that it was highly expressed in glioblastomas. This outstanding research team is beginning to uncover its role in one of the deadliest cancers. We hope this research will lead to finding better treatments and, one day, a cure,” says Tomás Guilarte, scientist, professor, and dean of Stempel College, who was a senior author of the study.
Glioblastoma and Neuroinflammatory Protein
To further investigate the sex differences in glioblastoma, and establish a correlation between the TSPO polymorphic variant rs6971, the study team analyzed the blood samples of 441 glioblastoma males and female patients.
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The study thereby uncovers a new link for bringing both the scientific and medical community closer to understanding the reason behind the deadliest nature of glioblastoma in males than females.
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Source-Medindia