About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Bioengineered Protein to Fight Leukemia

by Sheela Philomena on February 21, 2011 at 12:08 PM
Font : A-A+

 Bioengineered Protein to Fight Leukemia

Scientists have done a breakthrough in understanding body fighting mechanism against leukemia. CD19-ligand (CD19-L) protein acts as a good therapeutic target.

They have identified a protein called CD19-ligand (CD19-L) located on the surface of certain white blood cells that facilitates the recognition and destruction of leukemia cells by the immune system.

Advertisement

This work represents the first report of a bioengineered version of CD19-L, a recombinant human biotherapeutic agent, targeting CD19-positive leukemic stem cells.

The study was conducted by researchers at the Children's Center for Cancer and Blood Diseases and The Saban Research Institute of Children's Hospital Los Angeles.
Advertisement

B-lineage acute lymphoblastic leukemia (ALL) is the most common cancer occurring in children and adolescents. Despite having received intensive chemotherapy, some patients have recurring disease. For these individuals, the prospect of long-term survival is poor.

Lymphocytes are a type of white blood cell involved in immune function and are categorized as either B-cells or T-cells.

This newly discovered element, CD19-L, is expressed on the surface of T-lymphocytes and allows them to selectively bind to the CD19 receptor on the surface of B-lineage leukemia cells, and most importantly on leukemic stem cells responsible for the survival and expansion of the leukemia cell population.

Once the CD19-L binds to leukemia cells, cell death occurs. Although CD19 is abundantly expressed on leukemia cells from B-lineage ALL patients, it is absent on red cells, T-cells, and normal bone marrow stem cells, making it specific, and therefore, a good therapeutic target.

Lead author Fatih Uckun and colleagues have bioengineered and prepared a highly purified liquid formulation of the human CD19-L protein.

This recombinant protein not only shows selective binding to leukemia cells but also causes their rapid destruction within 24 hours. Perhaps most importantly, CD19-L killed even those leukemia cells that were highly resistant to both standard chemotherapy drugs as well as radiation.

The identification of CD19-L may lead to therapeutic innovation for childhood leukemia by allowing a selective destruction of leukemic stem cells.

The study has been published in the British Journal of Haematology.

Source: ANI
Advertisement
Advertisement
Advertisement

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Bioengineered Protein to Fight Leukemia Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests