About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Biochip Production may Speed-up Deadly Disease Diagnosis

by Rajashri on August 25, 2008 at 4:58 PM
Font : A-A+

Biochip Production may Speed-up Deadly Disease Diagnosis

A way to speed-up the production of biological ''chips'', paving the way for rapid tests for serious diseases and MRSA infections and faster discovery of new drugs has been devised by scientists at The University of Manchester.

Reporting their work in a paper in the Journal of the American Chemical Society (JACS), the researchers have described 'protein chips' as objects that have proteins attached to them, and that allow important scientific data about the behaviour of proteins to be gathered.

Advertisement

The Manchester team of Dr Lu Shin Wong, Dr Jenny Thirlway and Prof Jason Micklefield say that functional protein arrays may help run tests on tens of thousands of different proteins simultaneously, observing how they interact with cells, other proteins, DNA, and drugs.

Being able to place and locate proteins on a ''chip'' may make it possible to generate large amounts of data with the minimum use of materials, especially rare proteins that are only available in very small amounts, say the researchers.
Advertisement

They insist that their approach offers a reliable new way of attaching active proteins to a chip.

The researchers say that they have engineered modified proteins with a special tag, which makes them attach to a surface in a highly specified way, and ensures that they remains functional.

According to them, the attachment take place in a single step in just a few hours, and does not require any prior chemical modification of the protein of interest or additional chemical steps.

Prof Jason Micklefield from the School of Chemistry, said: "DNA chips have revolutionised biological and medical science. For many years scientists have tried to develop similar protein chips but technical difficulties associated with attaching large numbers of proteins to surfaces have prevented their widespread application. The method we have developed could have profound applications in the diagnosis of disease, screening of new drugs and in the detection of bacteria, pollutants, toxins and other molecules."

The researchers are presently working as part of a consortium of several universities on a 3.1 million-pound project, aimed at developing so-called ''nanoarrays'' that would be much smaller than existing ''micro arrays''.

They say that such nanoarrays would allow thousands more protein samples to be placed on a single ''chip'', reducing cost and vastly increasing the volume of data that could be simultaneously collected.

Source: ANI
RAS/L
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Black Pepper as Preventive Measure Against Omicron
FODMAP Diet: A Beginner's Guide
Smallpox
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
Drug-resistant Bugs may Be Battled by Experimental Drug
Experiments on mice conducted at the University of Texas Southwestern Medical Center in Dallas ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use