About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Better Insights into Armc5 Protein's Role in Development, Immune Response

by Dr. Trupti Shirole on February 9, 2017 at 4:46 AM
Font : A-A+

 Better Insights into Armc5 Protein's Role in Development, Immune Response

Cushing syndrome is an adrenal gland disorder that triggers hypertrophy of the glands and an increase in cortisol, an important hormone that suppresses inflammation and protects against stress. Genetic mutations of Armc5 are associated with the occurrence of this rare type of Cushing syndrome, suggests previous studies.

Genetic mutations of the Armc5 gene disrupt fetal development and compromise the immune response. Such are the findings of a study conducted by a team of Quebec researchers including Professor Alain Lamarre of Centre INRS-Institut Armand-Frappier.

Advertisement


The results of this study, which was recently published in Nature Communications, shed light on the vital role this protein plays in fetal development and in T-cell and adrenal gland biology. A better understanding of the mechanisms of action of ARMC5 could lead to new treatments for endocrine disorders.

The study showed that this protein's RNA is highly expressed in the thymus and adrenal glands. Development of a new Armc5-deficient experimental model highlighted the essential role this protein plays in the early activation phase of T-cells, which contribute to the immune response. "The new experimental model will provide better insight into this protein's role in the immune response," said Professor Lamarre.

Further studies will be needed to learn more about the modes of action of ARMC5, whose function depends on the interaction with other proteins.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Hypertension Day 2022 - Measure Blood Pressure Accurately, Control It, Live Longer!
Drinking This Popular Beverage May Drop Dementia Risk
Worst Mistakes Parents Make When Talking to Kids
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Myasthenia Gravis 

Most Popular on Medindia

Daily Calorie Requirements Drug - Food Interactions Hearing Loss Calculator Blood Pressure Calculator Blood Donation - Recipients Drug Side Effects Calculator Iron Intake Calculator Nutam (400mg) (Piracetam) How to Reduce School Bag Weight - Simple Tips Vent Forte (Theophylline)

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use