About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Beta-lactone to Attack Tuberculosis

by Anjali Aryamvally on December 30, 2017 at 12:23 PM
Font : A-A+

Beta-lactone to Attack Tuberculosis

Research teams from the Technical University of Munich (TUM), as well as Harvard University and Texas A&M University in the USA have found a new ally in the search of new strategies against life-threatening tuberculosis infections. They discovered a substance that interferes with the mycomembrane formation of the bacterium. It is effective even in low concentrations and when combined with known antibiotics their effectiveness is improved by up to 100-fold.

Among the greatest challenges when treating life-threatening tuberculosis infections is the increasing resistance to antibiotics. But the pathogen itself also makes the life of doctors difficult: its dense mycomembrane hampers the effect of many medications. A team of scientists headed by Stephan A. Sieber, Professor of Organic Chemistry at TU Munich, has discovered a substance that perturbs the formation of this membrane significantly.

Advertisement


The mycomembrane of the tuberculosis pathogen Mycobacterium tuberculosis consists of a lipid double layer that encapsulates the cell wall, forming an exterior barrier. Structural hallmarks are mycolic acids, branched beta-hydroxy fatty acids with two long hydrocarbon chains.

The team hypothesizes that similarly structured beta lactones could "mask" themselves as mycolic acid to enter the mycolic acid metabolic pathways and then block the decisive enzymes.
Advertisement

Helpful disrupter

In the context of an extensive search, the interdisciplinary team of scientists hit the bullseye with the beta lactone EZ120. It does indeed inhibit the biosynthesis of the mycomembrane and kills mycobacteria effectively.

Using enzyme assays and mass spectroscopy investigations, Dr. Johannes Lehmann, a researcher at the Chair of Organic Chemistry II at TU Munich, demonstrated during his doctoral work that the new inhibitor blocks especially the enzymes Pks13 and Ag85, which play a key role in the development of mycomembranes.

EZ120 is effective even in low doses, easily passes the mycomembrane and exhibits only low toxicity to human cells. The combined application of this substance with known antibiotics showed a synergistic effect leading to significantly increased effectiveness."Vancomycin, a common antibiotic, and EZ120 work together very well," says Prof. Sieber, who heads the Chair of Organic Chemistry II. "When used together, the dose can be reduced over 100-fold.

"The scientists suspect that disrupting the mycomembrane enables antibiotics to enter the bacteria more easily. This is a new mode of action and might be a starting point for novel tuberculosis therapies.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First-Ever Successful Pig-To-Human Kidney Transplantation
World Osteoporosis Day 2021 -
Spirituality and Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Tuberculosis Tracheostomy Pleural Effusion Silicosis Screening Tests for Tuberculosis Fever Cough Symptom Evaluation Diet in Tuberculosis Stomach Tuberculosis Extra Pulmonary Tuberculosis 

Recommended Reading
Mycobacteria Response to Antibiotics Differs Based on Growth and Timing
The growth of the bacteria and the phase of the cell division cycle that bacteria were in when ......
Inhaled Corticosteroids Increase Risk of Non-tuberculous Mycobacterial Disease
Non-tuberculous mycobacteria are widely dispersed and increasingly found in the environment. In ......
Tuberculosis and Other Mycobacteria can be Killed With Vinegar
Acetic acid, the active ingredient in vinegar, is effective in killing mycobacteria, even the ......
'Survival Gene' Suppresses Mutation Rates in Tuberculosis Bacteria
A key 'survival gene' that prevents strains of tuberculosis (TB) from mutating into drug-resistant ....
Cough Symptom Evaluation
Cough is a symptom of a condition usually affecting the respiratory tract. It may be acute or chroni...
Diet in Tuberculosis
Patients with tuberculosis should eat a healthy diet so that they build up their immunity to fight a...
Extra Pulmonary Tuberculosis
Extra pulmonary tuberculosis is infection of tissues and organs other than the lungs by mycobacteriu...
Fever
Fever or Pyrexia is an elevation in normal body temperature. Causes of fever include infections, inj...
Pleural Effusion
Pleural effusion is the accumulation of fluid in the space between the two coverings (pleura) of the...
Screening Tests for Tuberculosis
Tuberculin skin test and Interferon – Release Assays are tests used to screen for tuberculosis....
Silicosis
Silicosis is a lung disease caused by inhalation of crystalline free silica dust. It is characterise...
Stomach Tuberculosis
Abdominal tuberculosis, which is a form of extrapulmonary tuberculosis, affects the gastrointestinal...
Tuberculosis
Tuberculosis, caused by Mycobacterium tuberculosis, primarily affects the lung. It may spread to oth...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use