About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Benefits of Changing Measure of Kidney Disease Progression: Study

by Himabindu Venkatakrishnan on June 4, 2014 at 10:31 AM
 Benefits of Changing Measure of Kidney Disease Progression: Study

Adopting new, more sensitive definition of kidney disease progression can speed up developing therapies for kidney disease, reveals a study published by JAMA. The study is being released early online to coincide with its presentation at the European Renal Association-European Dialysis and Transplant Association Congress.

Chronic kidney disease (CKD) is a worldwide public health problem, with increasing prevalence, poor outcomes, and high treatment cost. Yet, despite the availČability of simple laboratory tests to identify people with earlier stages of CKD, there are fewer clinical trials for kidney disease than for other common diseases. One contributing reason may be that the established CKD progression end point (i.e., a doubling of serum creatinine concentration from baseline, corresponding to a 57 percent reduction in estimated glomerular filtration rate [GFR]), is a late event, requiring long follow-up periods and large sample size, which limits the feasibility of kidney-related clinical trials. Improved methods for estimating GFR may allow using smaller decreases in estimated GFR as alternative end points to assess CKD progression, according to background information in the article.

Advertisement

Josef Coresh, M.D., Ph.D., of the Johns Hopkins Bloomberg School of Public Health, Baltimore, and colleagues with the Chronic Kidney Disease Prognosis Consortium, examined the association of decline in estimated GFR with subsequent progression to end-stage renal disease (ESRD; initiation of dialysis or transplantation). The study included 1.7 million participants with 12,344 ESRD events and 223,944 deaths after repeated measurements of kidney function over a 1 to 3 year baseline period. Data collection took place between 1975 and 2011.

The researchers found that declines in estimated GFR smaller than a doubling of serum creatinine concentration were strongly and consistently associated with subsequent risk of ESRD. A doubling of serum creatinine, corresponding to a 57 percent decline in estimated GFR, was associated with a greater than 30-fold higher risk of ESRD. However, over a 1- to 3-year period, a doubling of serum creatinine concentration was present in less than 1 percent of participants. In contrast, a 30 percent decline in estimated GFR was nearly 10 times more common and was associated with an approximately 5-fold increased risk of ESRD.
Advertisement

"These data provide a basis for understanding the trade-off between higher risk and lower prevalence in choosing a larger or smaller percentage change in estimated GFR as an outcome when studying CKD progression," the authors write.

"A doubling of serum creatinine concentration has been accepted by the U.S. Food and Drug Administration as a surrogate end point for CKD progression in clinical trials since 1993. Adoption of a lesser decline in estimated GFR as an alternative end point for CKD progression has the potential to shorten duration of follow-up, reduce costs, and increase efficiency of clinical trials. Consistency of effects over time suggests applicability for shorter as well as for longer trials, which is relevant for diseases that are progressing more rapidly or slowly, respectively."

Source: Eurekalert
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Hypertension News

Post-Clot Removal Blood Pressure Reduction Raises Safety Concerns
In the majority of cases, it is advisable to allow patients' blood pressure to self-regulate following endovascular treatment.
High Blood Pressure Alert: 25% of Indian Adults at Risk
Blood pressure (BP) is a silent killer that is progressively impacting Indians, regardless of age, affecting both the young and the elderly.
Blood Pressure Monitoring Goes High-Tech With Smart Wearables
Several AI-backed blood pressure-analyzing instruments are available to assist patients in monitoring their blood pressure and other crucial vital signs.
Young and Hypertensed: The New Norm?
In India, there has been an increase in high blood pressure cases among youngsters, highlighting the necessity for effective measures to increase awareness.
Poor Lifestyle Contributes to Hypertension Among Adolescents
High blood pressure is often referred to as the "silent killer" because it doesn't exhibit any noticeable symptoms like fever or infection.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
MediBotMediBot
Greetings! How can I assist you?MediBot
×

Benefits of Changing Measure of Kidney Disease Progression: Study Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests