People with opioid use disorder, use of buprenorphine reduces mortality and periods off treatment are linked with much higher mortality rates. A study of 713 new outpatient users of buprenorphine was conducted in France, where patients with opioid use disorder are usually treated by general practitioners in private practice with periods in and out of treatment.
‘Buprenorphine, an opioid drug used to treat opioid addiction, moderate acute pain and moderate chronic pain should be administered to patients without any interruptions during treatment.’
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The mortality rate for study subjects was 0.63/100 person-year [95 percent CI 0.40- 0.85], compared to 0.24/100 person-year [0.24-0.25] for other individuals of the same age range during the same time period. The authors encourage physicians to avoid interruption of treatment and encourage patients to remain in treatment for a sufficient amount of time.
Source-Eurekalert