About My Health Careers Internship MedBlogs Contact us

Behavioral Approach Reduces Cognitive Fatigue in Multiple Sclerosis

by Vaishali Gokulakrishnan on September 23, 2017 at 5:43 PM
Font : A-A+

Behavioral Approach Reduces Cognitive Fatigue in Multiple Sclerosis

A recent article by Multiple Sclerosis research team describes a new non-pharmacological approach to reduce cognitive fatigue, a disabling symptom reported by as many as 90 percent of individuals with multiple sclerosis (MS).

Using functional neuroimaging, they demonstrated that the prospect of monetary reward stimulates the fronto-striatal network, resulting in the reduction of cognitive fatigue in individuals with MS and healthy controls. This is the first study to demonstrate this effect in an MS population.


The article, "Fronto-striatal network activation leads to less fatigue in multiple sclerosis" was published online in Multiple Sclerosis Journal. The authors are, Ekaterina Dobryakova, PhD, Angela Spirou, MS, Nancy Chiaravalloti, PhD, Helen Genova, PhD, Glenn Wylie, DPhil, and John DeLuca, PhD, of Kessler Foundation, and Hanneke Hulst, PhD, of VU University Medical Center, Amsterdam, The Netherlands.

Studies show that the fronto-striatal network is involved in cognitive fatigue, which can be modulated by both pharmacological and non pharmacological interventions. In this study, investigators examined the effects of a nonpharmacological intervention in 14 healthy controls and 19 individuals with MS.

All participants underwent functional MRI while performing a gambling task. They were tested under two conditions: 'outcome' and 'no outcome'. For the outcome condition, they were offered the opportunity to win a monetary reward; for the no outcome condition, no reward was offered.

"We found significant differences in activation between the two conditions in both groups," said Dr. Dobryakova, the lead author.

"With the outcome condition, significant activation of the frontostriatal network was associated with significant reduction in fatigue, suggesting that behavioral interventions that motivate individuals to reach a particular goal may be an effective approach to reducing fatigue. These findings show that there's potential for treating cognitive fatigue in MS with noninvasive interventions that provide a goal, such as winning money (as in the current study), for example, or achieving a good score on a test."

Dr. Dobryakova, a research scientist at Kessler Foundation, was a recipient of a 2016 Switzer Research Fellowship by the National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR), and a 2015 Independent Investigator Grant from the National MS Society.

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
Memory Loss - Can it be Recovered?
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chronic Fatigue Syndrome Chemotherapy Chemotherapy Drugs Infectious Mononucleosis Top Health Tips to Overcome Tiredness Multiple Sclerosis Treatment and Modify Tired All The Time Optic Neuritis Autoimmune Disorders Chronic Fatigue Symptom Evaluation 

Recommended Reading
Gut Microbes may Influence Multiple Sclerosis Progression
Gut microbes may play a role in the neurodegeneration that characterizes multiple sclerosis (MS). .....
Potential Treatment Strategies for Multiple Sclerosis
The fatty coating that protects neurons in the brain and spinal cord, Myelin is destroyed in ......
Multiple Sclerosis Patient Skydives Over Mount Everest
A multiple sclerosis sufferer wants his act of skydiving over Mount Everest to send a message of ......
Human Gut Microbe That Treats Multiple Sclerosis Discovered
A human gut microbe can aid in treating autoimmune diseases like multiple sclerosis. This gut ......
Autoimmune Disorders
Autoimmune disorders occur when the immune system fails to recognize the body as ‘self’ and attacks ...
‘Chemo’ means medicine or ‘drug’; ‘therapy’ means ‘treatment’. Chemotherapy refers to the use of cy...
Chemotherapy Drugs
Chemotherapy drugs perform like ‘magic bullets’ to destroy cancer cells in the body....
Chronic Fatigue Symptom Evaluation
The causes of chronic fatigue are quite diverse, and vary from simple overexertion to heart disease ...
Chronic Fatigue Syndrome
Information about Chronic fatigue syndrome, or yuppie flu, which is a complex disorder, characterize...
Infectious Mononucleosis
Called also the kissing diesase, Mononucleosis is an infectious disease due to infection with the Ep...
Multiple Sclerosis Treatment and Modify
Multiple sclerosis is treated with drugs that modify the course of the disease, suppress immunity an...
Optic Neuritis
Optic neuritis is acute inflammation of the optic nerve. Optic nerve connects the eye to the brain a...
Tired All The Time
Tired All The Time (TATT) syndrome is not only about feeling of tired, however there are a host of o...
Top Health Tips to Overcome Tiredness
If you follow a healthy lifestyle and still feel tired, you should rule out all possible medical cau...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use