For the first time, scientists have identified stem cells capable of repairing skull and face bones in mice. This advancement may lead to new stem-cell therapies for craniofacial bone repair in future.
Professor Wei Hsu, University of Rochester Medical Centre, US, said that the goal is to understand and find stem-cell therapy for a skull deformity in infants, a condition known as craniosynostosis. Craniosynostosis often leads to developmental delays and elevated pressure in the brain.
Axin2 gene and a mutation that causes craniosynostosis in mice were studied. Due to a unique expression pattern of the Axin2 gene in the skull, their role in bone formation, repair and regeneration were focused.